Grouppe Kurosawa: Kurosawa kocktails™ and Cancer Control print)

Kurosawa kocktails™ and Cancer Control

1.9.2005
Grouppe Kurosawa has developed topical and oral cancer treatment protocols that are effective, inexpensive, non-toxic and non-patented.

Cancer is all around us. Malignant cells develop in our bodies every minute of every day of our lives. In 99.999% of the cases, the malignant cells are either too genetically unstable to survive or are recognized as foreign by our immune systems and destroyed. When we talk about cancer, we are really referring to a breakdown in our body’s ability to rid itself of abnormal cells.

Abnormal cells develop in the normal course of cell division or as a consequence of environmental mutagens, such as cigarette tar, and UV light. Skin cancer, especially melanoma, is growing at a very fast rate. For the most part, this cancer is caused by UV light that causes damage to the DNA in the skin. If the UV light-induced DNA breaks don’t get repaired correctly, the damaged cells can grow abnormally and form tumors. The best example of this is a rare genetic defect in the genes of the one or more DNA repair enzymes. The unfortunate children who inherit this defect cannot go out into the sun—ever. If they do, the UV light will cause cancerous lesions to develop in the areas of the skin exposed to the light. Everyone wants a nice deep tan. It makes us look more attractive and healthy. Unfortunately, sunburns are more dangerous than you can imagine, especially if they are combined with a defective immune response. Ask any dermatologist. Cancer only develops when our cells repair mechanisms or immune-based removal systems have broken down.

Most cancers develop at the site of a chronic inflammation. During an inflammatory response, damaged cells and invading white blood cells release a large amount of highly damaging free radicals into the tissues spaces. These free radicals serve many different functions, including the destruction of microorganisms. Phagocytic white blood cells, such as neutrophils and macrophages, are not all that intelligent. They do not know if they are eating a microorganism or cleaning up debris, such as cigarette tar in the lungs. The free radicals they release can kill microorganisms in the tissues, as well as induce substantial tissue damage. If this inflammation becomes chronic, the free radicals can damage the DNA and repair proteins of cells resulting in the formation of cancer cells.

The cancer-causing retrovirus Rous sarcoma virus, the first tumor virus ever discovered, illustrates this relationship brilliantly. Rous sarcoma virus causes sarcomas, or connective tissue tumors, in chickens and other birds. It is very deadly. In a culture dish in the laboratory, RSV and a group of similar avian sarcoma viruses cause monolayers of fresh chicken fibroblasts (the cells which form connective tissue or the material making up the interior of your organs) to round-up and form clumps. These are classic characteristics of cancer cells. However, in the body RSV only forms tumors under certain circumstances. For example, when the RSV virus is introduced into a chicken in an aerosol form, i.e. the chicken breathes the virus into its lungs, the virus spreads throughout the body infecting fibroblasts in virtually every organ. Surprisingly, it doesn’t cause cancer anywhere in the body. How can a virus be so pathogenic in a culture dish, yet be so benign in the body? Is the immune system removing the cancer cells as quickly as they are formed? Studies have found no evidence that individual cancer cells are being formed at all in the chickens that inhaled the virus.

The story gets more interesting. If this viremic chicken is poked with a clean, sterile pin, a tumor will develop at the site of the localized inflammation, but no where else. Remember, the tumor virus has infected the entire body, but the tumor only develops at the site of the localized injury. Scientists found that transforming growth factor-beta (TGF-b), a multifunctional immune hormone, was released from platelets (cells that form blood clots) at the site of the pin prick, and that this hormone “permitted” RSV infected cells to become cancerous and form tumors. TGF-b accomplishes this unique task in two fundamental ways. Please bear with us for a moment, because this argument is important to understand. First, TGF-beta interferes with cell-cell communication, and this promotes cell growth. This has been demonstrated quite clearly in mammary or breast tissues. Once cells begin to divide, the RSV, a retrovirus that is only stable when its DNA is integrated into the DNA of the cell (this is the exact reason the HIV virus, another retrovirus, cannot infect quiet or non-activated cells), integrates into the now exposed DNA of the dividing cells and begins to make its viral proteins. One of these proteins, pp6O-vsrc, is the actual protein that causes the cancerous changes in the infected cells, but it cannot do so in the body without help from TGF-b.

After the cells begin to divide and transform themselves into cancer cells, they begin to form small clumps, but they don’t form tumors without even more help. Tumor cells require a steady supply of blood in order to grow into tumors. Normal organs couldn’t function without a steady blood supply, but the dependence on a steady blood supply is more critical for tumors. They are rapidly growing cells with pronounced nutritional needs. Blood transports nutrients and growth factors, removes toxic waste products and supplies oxygen to cells. Think of tumors as small, artificial organs. Just like organs, they will die if something interferes with their blood supply. Tumors only develop when the cancer cells become capable of stimulating small blood vessels to grow into their tissue mass. They do this by secreting factors that promote angiogenesis or the growth of endothelial cells, the cells that form capillaries. If these angiogenesis factors are blocked or inhibited, the tumors become starved for oxygen and nutrients and die in a pool of their own toxic waste. In scientific terms, they become necrotic. Tumor cells that split off from the main tumor cannot seed other organs (metastasize) if they are incapable of secreting angiogenesis-inducing factors. Some tumors, such as breast cancer, are particular good at metastasizing to other organs, while other more benign tumors rarely do so. The secretion of TGF-b and other angiogenesis factors is one of the principle factors that define the metastatic potential of particular cancers.

In addition to the stimulation of angiogenesis, many tumors develop by escaping immune surveillance. They do this by secreting other factors that inhibit the activation of cytotoxic T cells and other immune cells, such as natural killer cells, which normally recognize the presence of cancer cells and eliminate them. Some of these inhibitory factors are fairly general, e.g. they are routinely secreted by many different types of cancer cells, while others are specific for individual tumors. It is generally agreed that most cancer cells are poorly immunogenic. The so-called tumor antigens that distinguish these cells from normal cells are not very good stimulators of the immune system. Other cancers, such as melanoma, harbor very potent tumor antigens on their surfaces, yet this cancer, as a case in point, is obviously escaping immune surveillance because the incidence of melanoma is reaching epidemic proportions, especially in Australia and the southern states of the US. What’s the problem? The problem is that melanoma cells and other cancer cells secrete inhibitory factors that block immune recognition, as already indicated. The so-called poor immunogenic nature of many tumors may actually have little or nothing to do with the nature of their tumor-specific antigens and everything to do with the nature of the inhibitory factors they secrete. Recently, it was found that a major angiogenesis factor secreted by tumors actually inhibited dendritic cell development. In the absence of dendritic cells, newly formed T cells cannot be “taught” to recognize and kill tumor cells. This factor served a dual purpose in the growth of the tumor. It stimulated blood capillary growth into the tumor, while simultaneously inhibiting the immune response against the tumor by blocking the activation of naïve cytotoxic T cells. A deadly, dual punch, so to speak.

No One Ever Claimed Treating Cancer Was Going To Be Easy

According to the American Cancer Society, 180,200 new breast cancer and 334,500 new prostate cancer cases were reported in 1997. In 2004, they estimate that 211,000 new breast cancer diagnoses will be made. In the absence of massive chemotherapy or whole body radiation, no one knows if a cancer treatment will eliminate every cancer cell in the body. Biotech and pharmaceutical companies are working overtime trying to develop drugs that either replace or complement chemo/radiation. A recent report found that 409 cancer drugs were in development in the US alone. It is the position of Grouppe Kurosawa that most of these drugs are unnecessary.

The current outlook for cancer treatment is very discouraging. The percentage of Americans dying of cancer is still what it was in 1950. 1.4 million Americans will develop cancer of some type this year, 2004. One in two men and one in three women will develop cancer in their lifetimes. Cancer is rapidly replacing heart disease as the number one killer in America and in other Westernized countries.

As far as science is concerned, we can no longer claim that we don’t understand cancer. We understand it extremely well, but all our efforts thus far have not produced very many drugs or treatment protocols that consistently are effective against cancer. One of the problems, surprising perhaps to members of the general public, is that scientific models of tumor growth, often developed in mice, do not work. Andy Grove, Chairman of the Intel Corporation, and a prostate cancer survivor, recently referred to the collective scientific effort to control cancer as “like a Greek tragedy.” This is an understatement.

In March 2004, the medical computer database Medline identified 960 scientific papers that studied the effects of natural products (usually plant derived) on breast cancer. 470 scientific papers were identified that studied the effects of natural products on prostate cancer. The conclusions reached by these scientific studies are rarely reported in the popular press. These studies, or most of them, were performed under perfect conditions, such as in culture dishes or in genetically identical mice. Although these compounds have potential, they will never reach their potential as true anti-cancer agents unless they are reformulated or at least introduced into the body by a method that allows them to be therapeutically effective. Grouppe Kurosawa is not interested in searching the rain forests for new natural anti-cancer drugs. They already exist. We are simply interested in reformulating them and getting them into the body as quickly and effectively as possible.

And Now For Something Completely Different

Grouppe Kurosawa has and will continue to develop treatment protocols for cancers and leukemias that are safe, effective, non-proprietary, do not require the use of prescription drugs, and are not adjuncts to toxic chemotherapy and irradiation therapies. These are stand alone therapies that can be administered without the help of a physician, although it isn’t recommended. Unfortunately, many people either do not have medical insurance or they are being treated by physicians who have closed minds. Either way, they are going to lose.

To illustrate the effectiveness of natural or non-chemo/radiation cancer therapies, we are going to tell you about two people, friends who trusted us, who had terrible cancers.

The first, John, had acute myeloblastic leukemia ( AML ). This is probably the most resistant leukemia to treat. He had the traditional chemotherapy, but it didn’t work. It rarely does with AML . His physician, an oncologist, sent him home to die. John’s family and friends nursed him back to health using supplements, vitamins and a healthier diet. In time, John’s AML disappeared from his blood. It didn’t really disappear, because blast cells were still in his bone marrow, but John, being the hard headed fool that he was, thought he was cured and stopped taking his supplements. The AML came back. Even though John knew the AML had returned, he refused to admit it to himself or his family. Finally, John bled to death internally because he could no longer make platelets in his bone marrow. John’s death was a tragedy, but the fact remains his family beat back the AML without the help of the medical community. We know why their protocol worked.

Anna is another case entirely. Her personal story has now been published in this folder. Anna had one of the worst breast cancers imaginable. It was inoperable because the lesion had broken through the skin and was moving up her chest, destroying her chest muscles, and possibly moving to her heart. Radiation was also ruled out due to the already extensive skin damage. The only alternative was chemo and Anna refused.

Anna developed breast cancer about 15 years ago. According to one of her physicians, Anna was one of the few women alive that had a type four localized breast lesion (adenocarcinoma). Type four breast lesions are the worst, but they are rare because most breast cancers are treated immediately after detection. Anna refused treatment because she had no faith in the medical community or their procedures. She felt they would make the lesion worse. Over the years the lesion grew slowly, finally breaking through the skin and spreading across her chest. The lesion putrefied (smelled horribly) and seeped large amounts of dark yellow lymph fluid. Anna had to wear a chest bandage during the day and sleep with a towel on her chest at night.

Anna tried a variety of alternative treatments. She even went to Europe for treatment and was considering a visit to Argentina . In the early stages of the disease, she didn’t want to be disfigured by having her breast removed, but she didn’t want to die either. The longer she waited, and opted for alternative treatments, the more extensive her lesion became. When her HMO began pressuring her about using chemo, she became very stressed and her cancer became worse. Key point, stress promotes cancer growth, but it doesn’t cause it. We’ll explain how and why this works in subsequent essays.

Eventually Anna contacted one of the members of Grouppe Kurosawa and asked for our help. We talked to her alternative doctor and agreed to help. After a few weeks, we told Anna that her that the treatment protocol adopted by her alternative doctor was not compatible with our own. We disagreed with almost everything he was recommending. After her commitment to that treatment protocol ended, and her cancer had not improved, she agreed to put herself in our hands. She listed every drug and supplement that she was taking and told us about her diet. We changed everything.

Anna’s chest lesion was so severe that it had to be attacked both topically and orally (systemically). This is exactly what we did.

First, we told Anna what herbal and non-herbal supplements she should swallow. She was asked to purchase coconut milk, add the ingredients, and bring the solution to a boil. As it cooled, she could thin it out with ½ and ½ milk so it wouldn’t solidify. When cool enough, she drank it. She did this twice a day.

Many interesting medical herbs and extracts are not soluble in water. A case in point is curcumin, the yellow coloring in curry powder. Curcumin has some powerful anti-cancer properties but it’s only about 1% soluble in water. This means if you take curcumin as a capsule, it will pass right through your body and never be absorbed. If you boil it in coconut milk, the large amount of lauric acid, a small saturated fat, in coconut milk (lauric acid is not present in virtually any other foods, therefore, it isn’t part of anyone’s diet) dissolved the curcumin (and virtually anything other water insoluble molecule) and helped it enter the body. Fats are absorbed directly into the lymphatic system in the intestines, bypassing the blood and liver, which makes them excellent carriers for promoting the uptake of medicinal compounds into the body. In brief, coconut milk (coconut oil really) turns an ineffective natural medicinal compound into an effective one. Since these compounds are not toxic, a person can ingest large amounts of them to combat their cancers without risk of adverse reactions. And the cost is minimal.

Second, we told Anna that we had to induce necrosis in her chest lesion ASAP. We wanted to literally liquefy her tumor mass. For this purpose, we used a topical formulation much like our Kurosawa kocktail™ for the introduction of ibuprofen into the body. Only we omitted the ibuprofen and added other compounds. We also asked Anna to purchase or borrow a 1-3mHz ultrasound wand that is frequently used in physical therapy. Ultrasound can make temporary holes in the skin and “shoot” a topical medicine up to 5 centimeters into the tissue. That’s a long way. She borrowed a machine from a physician friend and we collectively held our breath.

Anna applied the topical directly to her lesion and to the periphery and used the ultrasound. She had very little pain or blood associated with her chest lesion, although the lesion “wept” large amounts of dark yellow lymph fluid.

When Anna woke up, she had a black crust all over her lesion. The topical formulation, introduced via chemical topical enhancers (no DMSO at this time) and ultrasound induced massive tissue damage in her tumor, so much so that the cancer tissue almost immediately formed a scab or crust. Under the crust was nice pink skin. We were on the right track. Anna also developed a slight fever, which meant we succeeded in kick starting an acute inflammatory response to the lesion, something that didn’t exist before. If you recall, we said that most if not all cancers begin at sites of inflammation. Inflammation is not bad, but low level chronic inflammation can feed a tumor’s growth. Well, to quote an American icon the chef Emeril Lagasse, we intended to “kick it up a notch” and make the inflammation harmful to the lesion’s life. And we succeeded, but we were too aggressive in the beginning so we backed down and went slower.

Very quickly, the brown lymph fluid ceased to flow, being replaced by a slight clear discharge. The skin changed from opaque to white to deep red and back to pink. The smell disappeared. To this day, her lesion is a patch work of different colors, but it is healing. Rough, uneven areas of her skin have smoothed out to a more uniform appearance. Anna found that her urine was golden brown in the morning, when it never was before. The tumor junk was being dumped into the blood and filtered out the kidneys so we told her to drink lots of water with magnesium and potassium supplements.

When we added some of the more powerful natural medicinal compounds back to the topical, we reduced the dose by ten times. This time instead of a black crust, the lesion oozed a brown thick substance. The longer Anna used the ultrasound, the more brown ooze, or BO as we now call it, was found on her chest in the morning. Eventually, the brown ooze began to largely stop flowing. When this occurred, we increased the dose and induced further ooze flow. Anna’s chest lesion was very large and deep so the treatment had to be administered gradually.

This is when the healing process began, and the pain and itching began in earnest. These are signs of healing. The pain was due to sensory neurons migrating back into the lesion and the itching was caused by histamine secreting mast cells moving into the dead tumor areas. As the inflammation peaked, the cancer cells continued to die as the new cells migrated into the lesion. Had we not purposely induced an acute inflammatory reaction in her lesion, this would not have occurred.

Although Anna never had a CAT scan before our treatment began, her doctors told her in no uncertain terms that considering the HER+++ status of her cancer, and the physical appearance of the primary lesion, her cancer had already metastasized to other parts of her body. Anna knew they were probably right because she had a lump in her armpit. The lump was an inflamed lymph node, an indication of metastasis, an associated lymphoma, or a metastatic tumor. Either way, Anna was in trouble.

Anna finally had her CAT and bone scans a few weeks ago. It is early March, 2004 now. She has NO cancer in her body except for her chest lesion, which is drying up. The lump in her arm pit is gone, and she experiences little discomfort, except for the tenderness associated with the chest lesion. She still has cancer in her chest, and she will for some time to come, but much of the tumor mass has literally already been liquefied and wiped off. And that is not an exaggerated statement. Anna continues with her oral and topical protocol, and we continue to adjust it as necessary. In time, the immune response, activated by the inflammation we induced, will clean up the rest of the mess on its own.

Anna’s physicians were speechless. They couldn’t understand how her cancer could have “turned around”. Well, it didn’t do it on its own. Anna may never completely get rid of all her cancer cells. After all, there are no guarantees in life. But the residual cancer will be minimal and harmless. Anna, unlike John, will continue to take her Kurosawa kocktail™, and enjoy her life to the fullest extent possible.

In January, 2005, Anna’s lesion is completely healed with only a few surface “bumps” of cancer that are largely receding and drying up with continued daily application of improved topical treatment formulations.

Anna is once again happy.

In retrospect, you have to laugh. Consider the irony. Modern high tech medicine can’t get a grip on cancer without almost killing the patients with radiation, chemotherapy and other toxic drugs. Yet, all Grouppe Kurosawa did was take our extensive knowledge of how cancer cells “beat the system” to remain alive and use this information against them. We didn’t use any prescription drugs. The few commercial drugs that we did use were all purchased over the counter in drug stories. The natural products were also freely commercially available. The secret, if you want to call it that, is that we effectively combined these compounds, dissolved them in either isopropyl alcohol or coconut milk so they would be maximally bioavailable, and introduced them into the body using coconut milk and ultrasound. We wanted the oral drugs to directly enter the lymphatic system, not the blood, and we wanted a deep penetration of the topical compounds directly into the lesion. We accomplished both of our goals without undue pain or discomfort.

Sometimes, low tech is better than high tech, or didn’t they teach you that in Sunday school?