PEITC, Glutathione, and Synergy with Glutamine in the Treatment of Cancer/Leukemia
PEITC or phenethyl isothiocyanate is a natural compound found in broccoli, cauliflower and other vegetables. It is a potentially very powerful anti-cancer agent.
I have already written two Blogs on this topic.
http://grouppekurosawa.com/blog/2006/01/curcumin-and-cauliflower-halt-prostate.htm
http://grouppekurosawa.com/blog/2006/01/peitc-and-cancer-control.htm
PEITC toxicity toward cancer cells has been traced to its ability to form a complex with glutathione or GSH. This complex is literally pumped out of cancer cells, thereby depleting them of the critical anti-oxidant GSH. Cancer cells go to great lengths to insure that their intracellular concentration of GSH never decreases to critical levels. That would mean certain death to the cancer cells, but not to normal cells (which have completely different metabolisms).
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11984078&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11163331&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11859408&itool=pubmed_docsum
Our current cancer/leukemia protocol uses at least 45 grams of the amino acid L-glutamine a day in 3x15 gram portions in juice. Glutamine kills cancer cells in high concentrations by inactivating mTOR, and heat shock signaling pathways. Glutamate, a breakdown product of glutamine, inhibits both glutathione synthesis and the uptake of glutathione into the mitochondria (mitochondria cannot make their own GSH). This results in cancer cell death.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15609127&itool=pubmed_docsum
I have published numerous Blogs on glutamine and its importance in treating cancers and leukemias. You can find them by doing a Google search on this web site.
Now it appears that PEITC can synergize with glutamine to further deplete GSH levels in cancer cells. There are no papers published on this topic, but it makes common sense. The glutamine breakdown product glutamate inhibits GSH synthesis and its uptake into mitochondria. PEITC further depletes GSH by forming a complex with GSH that results in the combined molecule being pumped out of the cell. I cannot emphasize enough that GSH depletion kills cancer cells. This is why cancer/leukemia folks cannot take anti-oxidant supplements.
If someone can find a supplement source of PEITC, post a reply to this essay. Otherwise, learn to like broccoli, cauliflower, etc. And don't boil them. Steam the vegetables or eat them raw with a vegetable dip.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
I have already written two Blogs on this topic.
http://grouppekurosawa.com/blog/2006/01/curcumin-and-cauliflower-halt-prostate.htm
http://grouppekurosawa.com/blog/2006/01/peitc-and-cancer-control.htm
PEITC toxicity toward cancer cells has been traced to its ability to form a complex with glutathione or GSH. This complex is literally pumped out of cancer cells, thereby depleting them of the critical anti-oxidant GSH. Cancer cells go to great lengths to insure that their intracellular concentration of GSH never decreases to critical levels. That would mean certain death to the cancer cells, but not to normal cells (which have completely different metabolisms).
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11984078&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11163331&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11859408&itool=pubmed_docsum
Our current cancer/leukemia protocol uses at least 45 grams of the amino acid L-glutamine a day in 3x15 gram portions in juice. Glutamine kills cancer cells in high concentrations by inactivating mTOR, and heat shock signaling pathways. Glutamate, a breakdown product of glutamine, inhibits both glutathione synthesis and the uptake of glutathione into the mitochondria (mitochondria cannot make their own GSH). This results in cancer cell death.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15609127&itool=pubmed_docsum
I have published numerous Blogs on glutamine and its importance in treating cancers and leukemias. You can find them by doing a Google search on this web site.
Now it appears that PEITC can synergize with glutamine to further deplete GSH levels in cancer cells. There are no papers published on this topic, but it makes common sense. The glutamine breakdown product glutamate inhibits GSH synthesis and its uptake into mitochondria. PEITC further depletes GSH by forming a complex with GSH that results in the combined molecule being pumped out of the cell. I cannot emphasize enough that GSH depletion kills cancer cells. This is why cancer/leukemia folks cannot take anti-oxidant supplements.
If someone can find a supplement source of PEITC, post a reply to this essay. Otherwise, learn to like broccoli, cauliflower, etc. And don't boil them. Steam the vegetables or eat them raw with a vegetable dip.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
11 Comments:
How's this?
The Lab Depot
http://tinyurl.com/bpvpr
Steve wrote: If someone can find a supplement source of PEITC, post a reply to this essay. Otherwise, learn to like broccoli...
***
Broccosprouts, anyone?
http://www.broccosprouts.com
Brassica Foundation
http://www.broccolisprouts.com
Cruciferous vegetables treat potential carcinogens the way
Tony Soprano does a snitch. By the time members of the
cruciferous family are through with them, there's nothing left
but harmless substances to be excreted.
"Cruciferous vegetables' anti-cancer firepower comes from
phytochemicals called isothiocyanates, which stimulate our
bodies to break down potential carcinogens. Sulforaphane,
found in broccoli and in even more concentrated form in
broccoli sprouts, is a well-known isothiocyanate. It
stimulates the body to produce enzymes that detoxify
carcinogens. Among men and women aged 50 to 74 in a study
from Harbor UCLA Medical Center in Torrance, Calif.,
participants who ate the most broccoli (average: 3.7
half-cup cooked servings weekly) were only half as likely to
develop colorectal cancer as subjects who said they never
ate broccoli.
"Broccoli sprouts contain 20 to 50 times the amount of
sulforaphane in mature broccoli. That means you'll get as
much sulforaphane in a few tablespoons of broccoli sprouts as
in a pound of broccoli. When scientists at Johns Hopkins
University in Baltimore fed broccoli sprouts to rats for
several days, and then gave them carcinogens, the animals
developed smaller, fewer and slower-growing tumors than the
ones that didn't eat sprouts.
"Watercress contains a powerful compound called PEITC
(phenethyl isothiocyanate, if you're wondering), which is not
only cancer-preventive in general, but specifically blocks the
nicotine in cigarette smoke from causing lung tumors in
animals. PEITC is at its highest levels in raw watercress,
although some remains after cooking.
"Many cruciferous vegetables also contain indole-3-carbinol, a
compound that affects sex-hormone metabolism involved with the
progression of prostate, breast and ovarian cancers. Men
between 40 and 64 who ate three or more half-cup servings of
cruciferous vegetables a week were 41 percent less likely to
develop prostate cancer, according to researchers at the Fred
Hutchinson Cancer Research Center in Seattle.
MEET THE CRUCIFERS
Arugula Bok choy Broccoli Brussels sprouts Cabbage Cauliflower
Chinese cabbage Collard greens Daikon Kale Kohlrabi Mustard
greens Radishes Rutabaga Turnips Watercress
http://store.yahoo.com/iherb/broccoli.html
Does not contain watercress but this product has broccoli and other cruciferous veggies. Available at our local stores. See at www.naturesway.com
Description
Special blend of protective food nutrients from Cruciferous vegetables including a special broccoli extract that is 400 times as concentrated in active constituents as fresh broccoli, and provides 100 mcg of sulforaphane per capsule.
Usage
Cruciferous Protectamins contain Sulforaphane, which is a potent inducer of protective enzymes. Each capsule provides as much of these active compounds as over 3.5 oz. of fresh broccoli.*
Due the sprouts have the same problem as alfalfa sprouts (inducing lupus like syndrome)?
If not then yum!
http://tinyurl.com/cl4hy
---favee
PEITC Source;
http://www.sciencelab.com/page/S/PVAR/10423/SLP4081
Cost of therapy with this will depend on the dose recommended by Dr. Steve.
And the recommended dose of PEITC is........?
A couple more sources.......
http://www.labdepotinc.com/chemical_details~pid~P2130.aspx
http://www.sigmaaldrich.com/catalog/search/ProductDetail?ProdNo=253731&Brand=ALDRICH
This stuff is fairly expensive in pharmaceutical/purified form, don't know how much of an advantage it would be to eating a lot of watercress. Again, depending on the effective dose I suppose.
Here's a product from Life Extension Foundation.
http://tinyurl.com/d939d
I found this when I was trying to get a highly potent sulforaphane/isothiocyanate supplement for my dog's bladder cancer. Apparently, it's the highest concentration you can buy, 30mg/capsule. It's expensive, $30 or $1/capsule, patented by Johns Hopkins. If you see BroccoSprouts in the grocery store, they apparently came about as part of the same initiative, and that's probably the cheaper way to go:
http://www.yoursgs.com/faq.php
From the Broccosprouts.com website, it looks like it has 73mg sulforaphane glucosinolate per ounce, vs 62mg of PEITC in watercress per ounce.
http://www.broccosprouts.com/sprouts/faq.htm
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