Curcumin Inhibits AP-1 Signaling.
AP-1 is one of the major genetic gene regulatory factors in the body. It activates genes involved in inflammation, cancer, arthritis and many other biochemical pathways.
Anti-inflammatory steroids like hydrocortisone bind their receptors, and these now activated receptors form inhibitory complexes with AP-1. Now we know that curcumin behaves in a similar way.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=9674701&itool=pubmed_docsum
I am only citing one reference on curcumin's ability to inhibit AP-1 signaling, but dozens of studies have been published on this topic. Curcumin apparently inhibits AP-1 signaling in numerous different ways.
In subsequent Blog essays, I will discuss in detail how AP-1 promotes various disease pathways. The next Blog essay will discuss the role of AP-1 in the pathogenesis of rheumatoid arthritis.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
Anti-inflammatory steroids like hydrocortisone bind their receptors, and these now activated receptors form inhibitory complexes with AP-1. Now we know that curcumin behaves in a similar way.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=9674701&itool=pubmed_docsum
I am only citing one reference on curcumin's ability to inhibit AP-1 signaling, but dozens of studies have been published on this topic. Curcumin apparently inhibits AP-1 signaling in numerous different ways.
In subsequent Blog essays, I will discuss in detail how AP-1 promotes various disease pathways. The next Blog essay will discuss the role of AP-1 in the pathogenesis of rheumatoid arthritis.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
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