Vitamin D3, Vitamin A and The Prevention of Tumor Cell Immortality
This subject is complicated so forgive me if my explanation is not completely understandable.
Telomeres exist at the ends of chromosomes. As chromosomes replicate during cell division, the telomeres protect the chromosomes from damage and cell death. Yet telomere function declines as cells continue to divide, and the ends of chromosomes become progressively shorter. After a prescribed numer of cell divisions, the cell die. This is referred to as the limited lifespan of somatic cells. As cells grow, the ends of their chromosomes progressively shorten until they die...but NOT in cancer cells.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15520642&itool=pubmed_docsum
A more technical discussion of this phenomenon can be found in the following paper. Click the Acta Pharma... box to read the paper online.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15842766&itool=pubmed_docsum
Telomerase is the enzyme that corrects the shortening of the chromosomes as they continue to divide. This enzyme is not active in normal cells, but it is very active in at least 90% of all cancers and leukemias. This means that telomerase expressing cells can continue to divide over and over without fear of dying of old age.
Cancer cells that possess active telomerase activity can survive, while non-active varients will die. This is dogma and it is carved in stone. It doesn't make ANY difference if the cancer cells are activated by oncogenes, such as RAS, or if the cancer cells are of a particular genetic makeup, the chromosomes in these cells will shorten, causing the death of these cells, unless telomerase activity is activated.
There is no shortage of biotech companies out there who would give anything if they could only develop telomerase inhibitors.
They should stop trying. Vitamin D3 and vitamin A, combined, inhibit the SYNTHESIS of the catalytic unit of telomerase. This means that these two hormones will not allow cancer cells to divide indefinitely. And that ain't bad.
The following study was conducted in prostate cancer cells, but the principle applies to ALL cells.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=12939463&itool=pubmed_docsum
ONLY the heterodimer of vitamin D3 and vitamin A receptors can inactivate the teleomerase gene.
So get these supplements integrated into your daily routine.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
Telomeres exist at the ends of chromosomes. As chromosomes replicate during cell division, the telomeres protect the chromosomes from damage and cell death. Yet telomere function declines as cells continue to divide, and the ends of chromosomes become progressively shorter. After a prescribed numer of cell divisions, the cell die. This is referred to as the limited lifespan of somatic cells. As cells grow, the ends of their chromosomes progressively shorten until they die...but NOT in cancer cells.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15520642&itool=pubmed_docsum
A more technical discussion of this phenomenon can be found in the following paper. Click the Acta Pharma... box to read the paper online.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15842766&itool=pubmed_docsum
Telomerase is the enzyme that corrects the shortening of the chromosomes as they continue to divide. This enzyme is not active in normal cells, but it is very active in at least 90% of all cancers and leukemias. This means that telomerase expressing cells can continue to divide over and over without fear of dying of old age.
Cancer cells that possess active telomerase activity can survive, while non-active varients will die. This is dogma and it is carved in stone. It doesn't make ANY difference if the cancer cells are activated by oncogenes, such as RAS, or if the cancer cells are of a particular genetic makeup, the chromosomes in these cells will shorten, causing the death of these cells, unless telomerase activity is activated.
There is no shortage of biotech companies out there who would give anything if they could only develop telomerase inhibitors.
They should stop trying. Vitamin D3 and vitamin A, combined, inhibit the SYNTHESIS of the catalytic unit of telomerase. This means that these two hormones will not allow cancer cells to divide indefinitely. And that ain't bad.
The following study was conducted in prostate cancer cells, but the principle applies to ALL cells.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=12939463&itool=pubmed_docsum
ONLY the heterodimer of vitamin D3 and vitamin A receptors can inactivate the teleomerase gene.
So get these supplements integrated into your daily routine.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
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