EGCG and the Treatment of HIV
This is going to be a quick article because I have to run.
EGCG is a polyphenol from green tea. It has amazing medicinal powers, but major drawbacks as well. A 70% EGCG in 99% total polyphenols blend is the most reasonabilily priced product. In capsule form, this product is almost worthless since it concentrates in the intestines. If the product is mixed in fat, the fat can carry the product into the lymphatic system which is the home of the HIV virus. Unfortunately, 70% EGCG mixed with coconut milk as a fat carrier tastes terrible.
We have some new volunteers who have agreed to test a new HIV treatment protocol. The protocol will use EGCGSyn, a product made by Lutimax Nutraceuticals in Southern California. This product targets the EGCG to the lymphatic system and it has NO taste at all. The volunteers have never been treated with HIV drugs and their infections are relatively current. In short, we believe they have what is known as a CCR5 dominant infection.
We are using EGCG for a number of reasons. First it is a powerful proteasome inhibitor like HIV protease inhibitor drugs. Proteasome inhibitors prevent the release of virus from infected cells. Next, it inhibits the activity of a genetic factor called STAT1. We believe the activation of STAT1 by the HIV protein NEF, the only viral protein that can cause AIDS symptoms in special strains of mice, is FUNDAMENTAL to the disease process.
A few points. Complete references will follow in another document.
1. If you inhibit STAT1 in HIV infected macrophages, the cells die. Normal cells are not affected.
2. The death pathway TRAIL is absolutely responsible for Activated Induced Cell Death and the apoptosis of non-infected CD4 T cells.
3. The induction of TRAIL synthesis is dependent on STAT1.
4. CD8 antigen specific cytotoxic T cell responses, such as against the HIV virus, are inhibited by STAT1.
5. STAT1 inhibits STAT4, which is responsible for inducing cell mediated immunity.
6. STAT1 induces transcription of NADPH oxidase, a major inducer of oxygen free radicals and HIV synthesis.
7. STAT1 can be activated by hydrogen peroxide, a potent oxidant.
The viral protein NEF activates STAT1 by indirect means.
The viral protein GP120 binds CXCR4 and induces apoptosis via STAT1 mediated TRAIL activation. The binding of GP120 to CD4 or CCR5 receptors has NO affect on TRAIL synthesis.
Anti-oxidants and EGCG both inhibit STAT1 and its downstream effects. So that is what we are going to do.
Have to run now.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
EGCG is a polyphenol from green tea. It has amazing medicinal powers, but major drawbacks as well. A 70% EGCG in 99% total polyphenols blend is the most reasonabilily priced product. In capsule form, this product is almost worthless since it concentrates in the intestines. If the product is mixed in fat, the fat can carry the product into the lymphatic system which is the home of the HIV virus. Unfortunately, 70% EGCG mixed with coconut milk as a fat carrier tastes terrible.
We have some new volunteers who have agreed to test a new HIV treatment protocol. The protocol will use EGCGSyn, a product made by Lutimax Nutraceuticals in Southern California. This product targets the EGCG to the lymphatic system and it has NO taste at all. The volunteers have never been treated with HIV drugs and their infections are relatively current. In short, we believe they have what is known as a CCR5 dominant infection.
We are using EGCG for a number of reasons. First it is a powerful proteasome inhibitor like HIV protease inhibitor drugs. Proteasome inhibitors prevent the release of virus from infected cells. Next, it inhibits the activity of a genetic factor called STAT1. We believe the activation of STAT1 by the HIV protein NEF, the only viral protein that can cause AIDS symptoms in special strains of mice, is FUNDAMENTAL to the disease process.
A few points. Complete references will follow in another document.
1. If you inhibit STAT1 in HIV infected macrophages, the cells die. Normal cells are not affected.
2. The death pathway TRAIL is absolutely responsible for Activated Induced Cell Death and the apoptosis of non-infected CD4 T cells.
3. The induction of TRAIL synthesis is dependent on STAT1.
4. CD8 antigen specific cytotoxic T cell responses, such as against the HIV virus, are inhibited by STAT1.
5. STAT1 inhibits STAT4, which is responsible for inducing cell mediated immunity.
6. STAT1 induces transcription of NADPH oxidase, a major inducer of oxygen free radicals and HIV synthesis.
7. STAT1 can be activated by hydrogen peroxide, a potent oxidant.
The viral protein NEF activates STAT1 by indirect means.
The viral protein GP120 binds CXCR4 and induces apoptosis via STAT1 mediated TRAIL activation. The binding of GP120 to CD4 or CCR5 receptors has NO affect on TRAIL synthesis.
Anti-oxidants and EGCG both inhibit STAT1 and its downstream effects. So that is what we are going to do.
Have to run now.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
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