Curcumin Preparation and Bioavailability
Curcumin is getting lots of scientific interest these days. Every month additional scientific studies are published on the effects of curcumin on different biochemical pathways.
Just keep one thing in mind. The curcumin used in these laboratory studies was dissolved in alcohol or DMSO. In short, the curcumin was made soluble in certain solvents that do not translate well for introduction into the human body.
The following two papers studied the effects of 3.6 grams of oral curcumin, in capsules, on humans. The first study is quite clear that curcumin simply does not enter the body in sufficient quantities to be medically effective.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14997198
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15668484
In this study, oral doses of 3.6 grams of curcumin a day showed blood levels of 10nM. This is a VERY low concentration of curcumin. Yet, it was apparently enough to reduce prostaglandin E2 synthesis in colon cancer patients.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15501961
In order for curcumin to be maximally effective against cancer, it MUST be introduced into the body in a bioavailable form. Curcumin is almost totally insoluble in water. On the other hand, it is completely soluble in fat.
Curcumin dissolves readily in coconut milk or cream, especially if they are warm. There is NO reason to boil coconut milk or cream in order to dissolve curcumin. Never boil anything unless you are absolutely certain the heat will not damage the medicinal properties of the natural medicine. I have no idea how heat stable curcumin is for medicinal purposes. So don't boil it.
Curcumin that is dissolved in fat will be introduced into the lymphatic system with the fat. There is exactly where we want curcumin to be introduced into the body. The lymphatic fluid bathes all the tissues in the body. We are NOT interested in directly introducing it into the blood.
People complain about the taste of curcumin. So add other spices, such as turmeric, or other spices to the mix to change the taste.
How much curcumin do we need to treat cancer and leukemia? No one knows but I would recommend at least 10 grams a day, 5 grams twice a day dissolved in fat. Since curcumin is not toxic, why screw around with low doses?
You must use glutamine, at least 20 grams a day, with the curcumin to make it maximally effective. I blogged on this issue yesterday.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
Just keep one thing in mind. The curcumin used in these laboratory studies was dissolved in alcohol or DMSO. In short, the curcumin was made soluble in certain solvents that do not translate well for introduction into the human body.
The following two papers studied the effects of 3.6 grams of oral curcumin, in capsules, on humans. The first study is quite clear that curcumin simply does not enter the body in sufficient quantities to be medically effective.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14997198
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15668484
In this study, oral doses of 3.6 grams of curcumin a day showed blood levels of 10nM. This is a VERY low concentration of curcumin. Yet, it was apparently enough to reduce prostaglandin E2 synthesis in colon cancer patients.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15501961
In order for curcumin to be maximally effective against cancer, it MUST be introduced into the body in a bioavailable form. Curcumin is almost totally insoluble in water. On the other hand, it is completely soluble in fat.
Curcumin dissolves readily in coconut milk or cream, especially if they are warm. There is NO reason to boil coconut milk or cream in order to dissolve curcumin. Never boil anything unless you are absolutely certain the heat will not damage the medicinal properties of the natural medicine. I have no idea how heat stable curcumin is for medicinal purposes. So don't boil it.
Curcumin that is dissolved in fat will be introduced into the lymphatic system with the fat. There is exactly where we want curcumin to be introduced into the body. The lymphatic fluid bathes all the tissues in the body. We are NOT interested in directly introducing it into the blood.
People complain about the taste of curcumin. So add other spices, such as turmeric, or other spices to the mix to change the taste.
How much curcumin do we need to treat cancer and leukemia? No one knows but I would recommend at least 10 grams a day, 5 grams twice a day dissolved in fat. Since curcumin is not toxic, why screw around with low doses?
You must use glutamine, at least 20 grams a day, with the curcumin to make it maximally effective. I blogged on this issue yesterday.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)
7 Comments:
If these promising results--such that more and more studies about curcumin are published every day--came about from curcumin dissolved in alcohol or DMSO, why is it necessary to dissolve curcumin in coconut oil?
This is a very strange question. Are you going to drink curcumin dissolved in alcohol or DMSO? Besides I want it targeted to the lymph in fat.
Mabe transdermal absorption with DMSO. Soon it will be a fashion to go yellowish!
N.
My question is strange because I don't understand how, if curcumin + coconut milk (C + CM) goes down the hatch, it targets the lymph any more efficiently than bacon 'n eggs. It's kinda like the Budwig flaxseed oil + cottage cheese (FO + CC) enigma. Each of these combinations (C + CM and FO + CC) go from mouth to stomach, to be churned in the gut just like chips 'n dip. Why either one of them should be treated by the human digestive system any differently than peanut butter 'n jelly is still a mystery to me. But, then, I'm not a scientist.
Fat by pas the stomach without being digested. It is when it reaches the small intestine where it is emulsified, digested and absorbed.
N.
http://www.getfitla.com/diet_fat.htm
Have you tried LEF's Super Curcumin w/Bioperine?
Have you tried Bioperine and Paw Paw?
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