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Thursday, August 14, 2008

Worm Pills, an Effective Treatment for Malignant Melanoma and Other Cancers

This essay is reposted from our subscription blog in the public interest.

Mebendazole is a generic, inexpensive prescription medicine used to treat worm infections. This drug is called a spindle poison because it interrupts the formation of microtubules, cellular filaments that separate newly made DNA. Chemo drugs such as Taxol and alkylating agents are also spindle poisons, but they have toxicities that mebendazole does not have.



http://en.wikipedia.org/wiki/Mebendazole



http://www.mayoclinic.com/health/drug-information/DR600879



In the last few years, a number of studies have found that mebendazole is a powerful inducer of apoptosis in a wide variety of cancer cells, both in culture dishes and mouse models.



In the following study, half maximal cytotoxic doses of mebendazole in the range 0.1 to 0.8 microM (VERY low) killed a wide diversity of cancer cells, including lung, breast, ovary, colon and osteosarcomas. These studies were also conducted in mice. Mebendazole also inhibited angiogenesis.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12231542&itool=pubmed_docsum



Unlike microtubule disruptive drugs such as Taxol and alkylating agents, mebendazole does not harm normal cells.



The following study was published this month. It shows that mebendazole kills two different strains of chemotherapy resistant melanoma cells. One strain contained a mutant p53 protein while the other harbored a normal p53 tumor suppresor protein. Mebandazole kills the cells equally. The half maximal cytotoxic dose was 0.32 microM.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18667591&itool=pubmed_docsum



Cimetidine, the generic version of the anti-ulcer drug Tagamet, promotes the toxicity of mebendazole by inhibiting its degradation in the liver.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3663452&itool=pubmed_docsum



The average blood concentration of mebendazole after a single clinical dose is 1.67 microM. This value vastly exceeds the concentration of mebendazole needed to kill a host of different cancer cells.



Mebendazole is usually sold as a chewable tablet. When chewed and allowed to remain in the mouth for a short period, the mebendazole can enter the blood through the mucosal membranes of the mouth. Of course, it can also enter the blood via the GI tract. This drug is extremely non-toxic even in doses of 4.5 grams a day.



Microtubule inhibitors are THE target of interest for chemo drugs. In this case, a simple anti-worm drug inhibits microtubule functioning at low non-toxic concentrations. In a culture dish and in mice, mebendazole induces apoptosis in a diversity of cancer cells at extremely low concentrations.



Unfortunately, this drug will NEVER enter clinical trials as a treatment for cancer.  There is no money to be made.



Fortunately, physicians can prescribe this drug for the treatment of cancer without a clinical trial. This blog and the referenced articles contain all the scientific justification that they will need.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Saturday, August 02, 2008

CDC Under Estimates New HIV Infections in US

CDC understated number of new HIV infections in US
By MIKE STOBBE, AP Medical Writer 28 minutes ago


The number of Americans infected by the AIDS virus each year is much higher than the government has been estimating, U.S. health officials reported Sunday, acknowledging that their numbers have understated the level of the epidemic.


The country had roughly 56,300 new HIV infections in 2006 — a dramatic increase from the 40,000 annual estimate used for the last dozen years. The new figure is due to a better blood test and new statistical methods, and not a worsening of the epidemic, officials said.


But it likely will refocus U.S. attention from the effect of AIDS overseas to what the disease is doing to this country, said public health researchers and officials.


"This is the biggest news for public health and HIV/AIDS that we've had in a while," said Julie Scofield, executive director of the National Alliance of State and Territorial AIDS Directors.


The revised estimate by the Centers for Disease Control and Prevention and the methodology behind it were to be presented Sunday, the opening day of the international AIDS conference in Mexico City.


Since AIDS first surfaced in 1981, health officials have struggled to estimate how many people are infected each year. It can take a decade or more for an infection to cause symptoms and illness.


One expert likened the new estimate to adding a good speedometer to a car. Scientists had a good general idea of where the epidemic was going; this provides a better understanding of how fast it's moving right now.


"This puts a key part of the dashboard in place," said the expert, David Holtgrave of Johns Hopkins University.


Based on the new calculations, officials believe annual HIV infections have been hovering around 55,000 for several years.


"This is the most reliable estimate we've had since the beginning of the epidemic," said Dr. Julie Gerberding, the CDC's director. She said other countries may adopt the agency's methodology.


According to current estimates, around 1.1 million Americans are living with the AIDS virus. Officials plan to update that number with the new calculations, but don't think it will change dramatically, a CDC spokeswoman said.


The new infection estimate is based on a blood test that for the first time can tell how recently an HIV infection occurred.


Past tests could only detect the presence of HIV, so determining which year an infection took place was guesswork — guesswork upon which the old 40,000 estimate was based.


The new estimate relies on blood tests from 22 states where health officials have been using a new HIV testing method that can distinguish infections that occurred within the last five months from those that were older.


The improved science will allow more real-time monitoring of HIV infections. Now, CDC officials say, the estimate will likely be updated every year.


Yearly estimates allow better recognition of trends in the U.S. epidemic. For example, the new report found that infections are falling among heterosexuals and injection drug users.


Some experts celebrated that finding, saying it's a tribute to prevention efforts, including nearly 200 syringe exchange programs now operating in 36 states despite a federal ban on funding for such projects.


But they also lamented the CDC's finding that infections continue to increase in gay and bisexual men, who accounted for more than half of HIV infections in 2006. Also, more than a third of those with HIV are younger than 30.


Some advocates say that suggests a need for more prevention efforts, particularly targeting younger gay and bisexual men.


For years, AIDS was considered a terrifying death sentence, and since 1981, more than half a million Americans have died. But medicines that became available in the 1990s turned it into a manageable chronic condition for many Americans, and attention shifted to Africa and other parts of the world.


Last week, President Bush signed a $48 billion global AIDS bill to continue a program that he called "the largest commitment by any nation to combat a single disease in human history."


But some advocates complain that CDC's annual spending on HIV prevention in the United States has been held to roughly $700 million since 2001, while costs have risen. (That's about 3 percent of what the federal government spends on AIDS; much of the rest is on medicines, health care and research.)


The new estimate is "evidence of a failure by government and society to do what it takes to control the epidemic," said Julie Davids, executive director of the Community HIV/AIDS Mobilization Project.


Whether more funding comes or not, the revised estimate clearly is a "wake-up call to scale things up," said Dr. Kevin Fenton, who oversees CDC's prevention efforts for HIV/AIDS.


Some said more attention needs to focus on prevention among blacks, who account for nearly half of annual HIV infections, according to the new CDC report.


A recent report by the Black AIDS Institute concluded that if black Americans were their own nation, they would rank 16th in the world in the number of people living with HIV.


"We have been inadequately funding this epidemic all along. We need to step it up," said former U.S. Surgeon General Dr. David Satcher, who is now an administrator at Atlanta's Morehouse School of Medicine.


The new estimate has been anticipated for a long time. The CDC began working on the new methods nearly seven years ago.


Late last year, advocates said they had heard the figure was about 55,000 and pressed the CDC to release it. Agency officials declined, saying they were submitting their research for medical journal review.


"These are extremely complicated statistical methods," and CDC officials wanted the work to be thoroughly reviewed by outside experts, Gerberding said. CDC's findings are being published in the Journal of the American Medical Association.


Until 1992, the number of diagnosed AIDS cases was used to predict how many people were newly infected each year. That method produced an estimate of 40,000 to 80,000. More recently, the CDC focused on infections among men who have sex with men, who account for about half of new HIV diagnoses.


___

Sunday, July 27, 2008

You Could Have Heard a Pin Drop

When in England , at a fairly large conference, Colin Powell
was asked by the Archbishop of Canterbury if our plans for Iraq were
just an example of empire building' by George Bush.

He answered by saying, 'Over the years, the United States has
sent many of its fine young men and women into great peril to fight
for freedom beyond our borders.
The only amount of land we have ever asked for in return is enough to
bury those that did not return.'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
There was a conference in France where a number of international

engineers were taking part, including French and American. During a
break, one of the French engineers came back into the room saying
'Have you heard the latest dumb stunt Bush has done? He has sent an
aircraft carrier to Indonesia to help the tsunami victims. What does
he intended to do, bomb them?'

A Boeing engineer stood up and replied quietly: 'Our carriers
have three hospitals on board that can treat several hundred people;
they are nuclear powered and can supply emergency electrical power to
shore facilities; they have three cafeterias with the capacity to feed
3,000 people three meals a day, they can produce several thousand
gallons of fresh water from sea water each day, and they carry half a
dozen helicopters for use in transporting victims and injured to and
from their flight deck. We have eleven such ships; how many does
France have?'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

A U.S. Navy Admiral was attending a naval conference that
included Admirals from the U.S. , English, Canadian, Australian and
French Navies. At a cocktail reception, he found himself standing with
a large group of Officers that included personnel from most of those
countries.

Everyone was chatting away in English as they sipped their
drinks but a French admiral suddenly complained that, whereas
Europeans learn many languages, Americans learn only English.' He then
asked, 'Why is it that we always have to speak English in these
conferences rather than speaking French?'

Without hesitating, the American Admiral replied 'Maybe it's
because the Brits, Canadians, Aussies and Americans arranged it so you
wouldn't have to speak German.'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

AND THIS STORY FITS RIGHT IN WITH THE ABOVE...

Robert Whiting, an elderly gentleman of 83, arrived in Paris by
plane. At French Customs, he took a few minutes to locate his
passport in his carry on.

'You have been to France before, monsieur?' the customs
officer asked sarcastically.

Mr. Whiting admitted that he had been to France previously.
Then you should know enough to have your passport ready.'
The American said,''The last time I was here, I didn't have
to show it.

'Impossible. Americans always have to show your passports on
arrival in France !'

The American senior gave the Frenchman a long hard look. Then
he quietly explained, ''Well, when I came ashore at Omaha Beach on
D-Day in 1944 to help liberate this country, I couldn't find a single
Frenchmen to show a passport to.'

You could have heard a pin drop.

Well said.

Grouppe Kurosawa, Medicine in the Public Interest
http://www.grouppekurosawa.com


________________________________

Saturday, July 26, 2008

The End of AIDS. Part Five

This essay is republished from our subscription blog in the public interest.

Adam, our first and only HIV success story, took at my recommendation 1.2 grams of ibuprofen a day for three months before he began our "formal" HIV treatment protocol. In retrospect, I believe the use of ibuprofen, a Cox-1 and Cox-2 inhibitor, contributed substantially to the rebound in his immune response against the HIV virus.



MAIDS, a form of mouse AIDS caused by a similar retrovirus, is completely reversed by the use of Cox-2 inhibitor drugs. Cox-2 enzymes produce PGE2, a powerful prostaglandin that increases the level of cyclic AMP in cells. Cyclic AMP, acting via the protein kinase A enzyme, is extremely immunosuppressive.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15344910&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11387259&itool=pubmed_docsum



When the HIV surface protein gp120 binds its CXCR4 co-receptor, it induces the synthesis of cyclic AMP and activates the protein A kinase pathway in infected and non-infected cells. This results in T cell anergy in normal cells. Anergy means the immune cells fail to respond to antigens. GP120 also activates the synthesis of Cox-2 via NF-kappaB.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12972513&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17627037&itool=pubmed_docsum



Protein kinase A is both immunosuppressive and an inducer of immunological tolerance. Tolerance means the immune response is literally taught to ignore certain antigen. This is an appropriate response AFTER an immune response has outlived its usefulness. However, if tolerance is induced early in an immune response, say against HIV viral proteins, the immune cells cannot recognize the viral proteins. Now you have a really big problem on your hands.



The Cox-2 inhibitor that we will use in this protocol is acetaminophen, Tylenol. This drug specifically blocks Cox-2 activity while leaving Cox-1 enzyme activity largely intact. In the presence of supplements such as n-acetylcysteine, acetaminophen does not cause liver damage. NAC is part of our HIV treatment protocol.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17884974&itool=pubmed_docsum



Psychological stress also plays a role in promoting the development of AIDS.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16314608&itool=pubmed_docsum



A current study at UCLA found that mindfullness meditation increases the CD4 T cell count and slows the progression of HIV. The study has not be published yet.



Almost all immune cells have beta1 and beta2 receptors on their membranes. These receptors bind adrenaline (epinephrine) and noradrenaline (norepinephrine) which increase the level of cyclic AMP in cells. Beta blockers are well known anti-hypertensive drugs. The medical and scientific communities have not come to grips with the role stress plays in the disease progression associated with HIV infections and cancer/leukemia. If the immune response is compromised by psychological stress, any and all efforts to increase immune responsiveness are rather pointless.



The best beta blocker is a drug called pindolol. Walmart sell a 3 months supply for $10. This drug blocks both beta 1 and 2 receptor activity. Further, it inhibits the release of noradrenaline from nerve endings. Noradrenaline is very immunosuppressive.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12458033&itool=pubmed_docsum



Pindolol is prescribed off label by physicians as a treatment for anxiety. The use of this drug will help control the immune suppression associated with psychological stress.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Wednesday, July 23, 2008

Glutamine and HIV

This essay is reposted from our subscription blog in the public interest.

Thus far, I have written over 1500 medical blog essays. As a result, I sometimes forget what I have already written. In the protocol essays, I forgot to mention that glutamine activates the synthesis of heat shock proteins.



Glutamine stimulates the synthesis and promotes the stability of the heat shock protein hsp-70.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18596307&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17599724&itool=pubmed_docsum



Glutamine, like low level glucosteroids, can protect against sepsis and shock. However, the glutamine response is completely dependent on the presence of HSP-70. Mice genetically deficient in HSP-70 are not protected by infusions of glutamine. The following review article, which can be read online, is an excellent review of the relationship between glutamine and HSP-70.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17234954&itool=pubmed_docsum



The term heat shock is actually a misnomer. These proteins protect the body against a wide variety of stressors, including excessive heat. HSP-70 protects the body against inflammation by inhibiting the activation of the genetic factor NF-kappaB. This well studied genetic factor activates the synthesis of a host of different pro-inflammatory immune hormones, including TNF. The inhibition of this factor is a major goal in the clinical control of cancer.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18282612&itool=pubmed_docsum



NF-kappaB is necessary for the activation of the HIV gene in infected cells.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16488488&itool=pubmed_docsum



In addition to its intracellular role, HSP-70 is also released from the cell into the tissue spaces. There it forms a complex with the membrane chemokine receptor CCR5, thereby blocking the infection of new CD4 T cells by certain strains of the HIV virus.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17251296&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16909434&itool=pubmed_docsum



In macrophages, HSP-70 forms a complex with the viral protein VPR, thereby preventing this viral protein from promoting the import of the virus into non-dividing macrophages.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15166037&itool=pubmed_docsum



VPR is also known to induce G2 arrest and death in infected CD4 T cells. HSP-70 prevents this response.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15142379&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15331702&itool=pubmed_docsum



I believe that AIDS, the final phase of HIV infection, can be strongly reversed by a combination of low dose hormone replacement glucosteroids and 50 grams, minimum, of the amino acid glutamine. For those who cannot get a prescription of these anti-inflammatory steroids, high glutamine doses may partially suffice. Glutamine can be purchased in bulk for $25USD/1 kilogram. The source is listed on our www.grouppekurosawa.com home page in the supplement file at the top of the page. We have no financial arrangement with this firm. They ship worldwide.



High doses of glutamine cannot be used in phase two of our treatment protocol. In this phase, we NEED NF-kappaB to be activated. NF-kappaB is necessary for the activation of both the innate and adaptive immune systems. Glutamine is obtained from the diet once the appetite returns.



Glutamine, by virtue of its ability to stimulate the synthesis and stability of HSP-70, is a powerful, inexpensive and non-toxic treatment for severe HIV infections.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Tuesday, July 22, 2008

The End of AIDS. Summary

In this essay, I am going to attempt to put together a viable HIV treatment protocol. I have tried this in the past, but the protocols did not work to my satisfaction. Go here goes...



First and foremost, the final phase of the disease, AIDS, must be reversed. I realize that this sounds impossible but it really isn't. AIDS, in my opinion, is characterized by a steadily progressing glucosteroid insensitivity. Virtually every clinical symptom associated with AIDS is identifical to that associated with adrenocortical insufficiency. Methylprednisolone, in low hormone replacement doses, has been used to block proinflammatory induced shock and death. This hormone can also be used to block the extreme inflammatory response that drives HIV infections into AIDS. Further, it can be used to reverse AIDS into a more benign viral infection, while restoring total body homeostasis.



Glutamine, in 50 gram doses, 25 grams twice a day in juice, is used to complement the low dose glucosteroid treatment. Glutamine also inhibits PI-3K/AKT signaling, thereby causing the death of long term viral reservoirs in macrophages.



ONLY glutamine and methylprednisolone are used to reverse AIDS. NOTHING ELSE.



Once AIDS is reversed, we can breathe freely while we attempt to erradicate the virus from the body.



When the body has stabilized and appetite and strength have returned, we can drop the methylprednisolone and concentrate on reactiving the immune response against the virus.



Low hormone replacement doses of methylprednisolone are not immunosuppressive. That is a contradiction in terms.



I want to strongly emphasize that the CD4 T cell count is irrelevant for our purposes here. It is a poor indicator of clinical status. There are people who have CD4 T cell counts of 10 who are not sick. Naturally, their innate immune response is still functioning. The innate arm of cellular immunity has nothing to do with CD4 T cells.



Second phase.



Hopefully, the glucosteroids have substantially reduced reduced the synthesis of TNF and other pro-inflammatory hormones that drive HIV infections into AIDS.



In this phase, we will use 50 mgs of elemental zinc per day. Zinc sulfate capsules of 220 mgs or so contain about 45-50 mgs of actual zinc. I capsule per day. The bottle will tell you how much zinc is present in each capsule. Do not exceed 50 mgs of zinc a day.



As I have written, zinc activates the entire immune response. Zinc also specifically activates PI-3K/AKT signaling, which is absolutely required for T cell development.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17509519&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17371229&itool=pubmed_docsum



Glutamine and arginine are necessary for proper immune functioning. If your appetite has returned, a person can get all the necessary glutamine and arginine from the diet. Arginine is found in high concentrations in nuts. High dose glutamine supplements are not necessary in this phase.



Alpha lipoic acid and n-acetylcysteine, taken together, will help to rebuild the glutathione levels in the body. Glutathione is necessary proper immune functioning. It is usually depleted in HIV infections.ALA works in the presence of retroviral drugs, but NAC does not. Together, they may help to increase the CD4 T count in the presence of these drugs. But don't hold your breath. Retroviral drugs are immunosuppressive. They may drop the viral titer, but they rarely increase the CD4 T cell counts.



The ALA dose is 300 mgs three times a day. The NAC dose is 600 mgs twice a day. ALA will also regenerate vitamin C and vitamin E in the body. You can take these supplements also, but not in excessive doses.

Acetaminophen is used to inhibit HIV induced PGE2 synthesis. This prostaglandin, via its activation of cyclic AMP, is very immunosuppressive. The dose is 2 grams a day, 1 gram twice a day.

Pindolol, a generic prescription drug, is used to block psychological stress induced immunosuppression. The dose is determined by your physician.



Summary



The immune system is quite durable. If you can remove the toxic factors which inhibit its activity, such as excessive TNF, FAS, and TRAIL apoptosis responses, it will regenerate itself.



In the first phase, we are attempting to enhance glucosteroid responsiveness using low dose hormone replacement doses. This will act to inhibit the inflammatory response that is driving the disease. Glutamine restores homeostasis in the body, while killing long term macrophage viral reservoirs by blocking PI-3K/AKT activity.



In the second phase we are attempting to support an enhanced immune response against the virus. We are not attempting to "activate" the immune response against the virus. The HIV virus and virally infected cells are very immunogenetic. In the absence of interfering factors, the immune cells will rapidly clear the virus. Thousands if not millions of people have been exposed to the HIV virus yet they remain healthy. Many of these people are seronegative, which means that the virus didn't last long enough in the body to stimulate an antibody response.



Pass this series of essays along to your friends. I realize that many physicians are afraid to prescribe glucosteroids to HIV infected persons because of a fear of immunosuppression. Hormone replacement doses are not immunosuppressive.The hormone replacement dose is only temporary anyway, but it MUST be used. If you don't inhibit the activity of the death hormones TNF, FAS and TRAIL, the disease process will continue. If you have money or insurance, you can elect to remain on HIV drugs until they eventually fail. Of course, your immune system will never reestablish itself due to the immunosuppressive nature of these drugs. Unfortunately most of the world has no access to these drugs so protocols like this are ideal.



It's worth a try. Nothing else is working.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com/

Monday, July 21, 2008

The End of AIDS. Part Four

This essay is reposted from our subscription blog in the public interest.


Glutamine is the most prevalent amino acid in foods. Since it can also be made in the body, it is considered a non-essential amino acid. NOTHING could be further from the truth.




During illness, the tissue stores of glutamine are rapidly depleted. This can be corrected with glutamine supplementation. Glutamine plays a fundamental role in virtually every aspect of cellular metabolism.




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11527675&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18443481&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17713406&itool=pubmed_docsum




It seems reasonable that people with advanced HIV infections suffer, to some extent, from glutamine depletion. This is certainly true in the last stage of the disease, AIDS. Therefore, glutamine supplementation should be given to these people as it is to other critically ill persons.




Some time ago I wrote an essay entitled "He just stopped dying". It was the story of a 70 plus year old man dying in a hospice of metastatic pancreatic cancer. After 50 grams of glutamine a day for 30 days, his bedsores healed, his appetite returned and he walked out of the hospice. According to his physician, he just stopped dying. This is the power of glutamine.


http://grouppekurosawa.com/blog/2008/04/he-just-stopped-dying




Glutamine is important for another reason. This amino acid inhibits the activity of the PI-3K/AKT signaling pathway. This pathway promotes the survival and growth of cancer and leukemia cells.




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18635390&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=14621121&itool=pubmed_docsum




PI-3K/AKT also plays a role in the continued synthesis of the HIV virus in tissue macrophages. These cells are long term reservoirs of viral synthesis which are NOT affected by current retroviral drugs. The activation of this pathway protects the macrophages from oxidative stress that could ordinarily kill the cells. If PI-3K/AKT is inhibited, these long term reservoirs of viral synthesis die.




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18237430&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18241337&itool=pubmed_docsum




Glutathione plays a fundamental role in immune responsiveness. As can be expected, glutathione depletion is common in HIV infections. Both n-acetylcysteine and alpha lipoic acid can be used to increase glutathione levels in the body. This improves immune responsiveness.




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18315507&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15798812&itool=pubmed_docsum




Unfortunately, glutathione elevating agents cannot be used in the presence of glucosteroids. Glutathione and enzymes that use glutathione as reducing agents cause glucosteroid resistance. This is the last thing that we want to happen, especially in the AIDS phase of the disease.




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12036455&itool=pubmed_docsum




http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11186134&itool=pubmed_docsum




In the final essay, I will summarize the information thus provided and present a formal treatment protocol.




Stay tuned...




Grouppe Kurosawa, Medicine in the Public Interest




http://www.grouppekurosawa.com/

Sunday, July 20, 2008

The End of AIDS. Part Three

This essay is reposted from our subscription blog in the public interest.

It is estimated that 25% of the population of the world is deficient in zinc. This deficiency is particularly prevalent in the elderly and vegetarians. The highest dietary concentration of zinc is found in meat.



Zinc plays many, many roles in the body by virtue of its ability to control the activity of over 300 "zinc finger" proteins. These proteins MUST bind zinc in order to be biologically active.



Many critically important zinc finger proteins are found in every cell in the immune system. If zinc becomes even slightly depleted, the immune response begins to fail. I cannot emphasize this point enough. The following review articles provide all the necessary background information. These articles can be read online.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9701160&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12730441&itool=pubmed_docsum



The elderly suffer from a low grade inflammation that contributes to chronic immune activation. They also suffer from mild zinc deficiencies. When zinc supplements are provided, these defects are corrected.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18279033&itool=pubmed_docsum



An excellent example of the importance of zinc in the immune response is typified by the immune hormone thymulin. This hormone is found in the thymus where it promotes the differentiation of immature T cells into mature CD4 and CD8 T cells. Thymulin is a zinc dependent hormone. When zinc concentrations become limiting, the CD4/CD8 ratio decreases.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3262625&itool=pubmed_docsum



Zinc is also a powerful anti-oxidant by virtue of its ability to increase the activity of enzymes such as catalase and superoxide dismutase. When alcohol is chronically fed to mice, their livers over express mRNA for TNF, its receptors, FAS ligand, and its receptors. Zinc supplementation largely prevented the over expression of these pro-inflammatory, pro-apoptotic immune hormones, thereby preventing alcohol from causing cirrhosis.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18375824&itool=pubmed_docsum



Zinc is frequently diminished in HIV infected people. Low zinc is associated with a low CD4 T cell count possibly due to the inhibition of thymulin activity in the thymus gland. 



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11049206&itool=pubmed_docsum



Zinc deficiency is particularly common in IV drug users. These people usually suffer from extreme malnutrition which naturally diminishes zinc uptake. Vegetables contain very little zinc and "junk" or highly processed foods contain almost none. This study confirms that zinc deficiency is associated with declining CD4 T cell counts and reduced survival.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12942385&itool=pubmed_docsum



Zinc supplementation increases the CD4 T cell count, and a reduced incidence of opportunistic infections, such as candida and pneumocystis carinii.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10801955&itool=pubmed_docsum



The maximum dose of zinc per day is 50 milligrams of elemental zinc. This figure should not be exceeded.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Friday, July 18, 2008

The End of AIDS. Part Two

This essay is reposted in from our subscription blog in the public interest.

In part one of this series, I presented evidence that low doses of glucosteroids can inhibit inflammatory responses on a long term basis, while high pharmacological doses can only do so temporarily.



Acute, in contrast to chronic, inflammatory responses are absolutely necessary to activate the immune system against pathogens. Since glucosteroid concentrations also increase during stress, the body must protect itself from an inappropriate glucosteroid mediated immunosuppression.



There are two glucosteroid cellular receptors. The alpha receptor activates glucosteroid controlled genes, while the beta receptor blocks glucosteroid signaling. Inflammatory hormones, such as TNF, induce resistance to glucosteroids by activating the beta receptor.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11381138&itool=pubmed_docsum



On the other hand, the synthesis and release of TNF and other inflammatory mediators, primarily released from tissue macrophages, is inhibited by the glucosteroid inhibition of NF-kappaB and other signaling pathways.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11506387&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=10748079&itool=pubmed_docsum



It is obvious that glucosteroids and TNF have a crosstalk relationship in modulating each other's actions in the body.



It is important to understand that an HIV infection is not AIDS. AIDS refers to the final terminal phase of the disease. Many people live with serious HIV infections for many years without ever developing AIDS.



Twenty years ago, a Japanese group published a review article suggesting that AIDS was a TNF driven disease. Today, scientists are finally beginning to take this suggestion seriously.



Last year a review article was published entitled "Is HIV infection a TNF receptor signaling-driven disease?"



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18178131&itool=pubmed_docsum



The answer appears to be yes.



The viral protein NEF and TNF both promote the synthesis of HIV in viral reservoirs such as monocytes and macrophages. The viral membrane protein gp120, binding the CD4/chemokine receptors, increases further TNF synthesis, which promotes additonal viral synthesis. This is called a feed forward cycle.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18336259&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16873189&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16081599&itool=pubmed_docsum



If this cycle proceeds unabated, the final phase of HIV infections, AIDS, will eventually develop.



Lets consider the evidence.



The membrane receptors for FAS and TNF, over expressed on macrophages, and their ligands are well known to be able to kill normal CD4 T cells. This is a characteristic feature of HIV infections.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11861282&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8996241&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9616211&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8523526&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12767990&itool=pubmed_docsum



It is VERY clear that viral proteins can induce the synthesis of all three death receptors (TNF, FAS and TRAIL) in monocytes/macrophages. The excessive expression of these receptors and their activators on monocytes drives the progression of HIV infections into AIDS by causing additional inflammation while simultaneously killing non-infected CD4 T cells.



It is also very clear that the presence of TNF and soluble forms of its receptors parallels the severity of HIV infection and the progression towards AIDS by chronic immune activation. Again, chronic immune activation is characteristic of HIV infections.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7744500&itool=pubmed_docsum



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7906293&itool=pubmed_docsum



As the level of TNF and other pro-inflammatory mediators increase in HIV infections, glucosteroid sensitivity will decrease. As in the case of Ms Kaye, hydrocortisone levels in the blood may be normal but the body has become resistant to the hormone. As far as I am concerned, this is the fundamental "trigger" that initiates progression towards AIDS.



Glucosteroids maintain the integrity of the body. Symptoms of glucosteroid insufficiency include muscle weakness, anorexia, diarrhea, mental confusion, abdominal pain, weight loss and extreme susceptibility to infections. Every one of these symptoms is associated with AIDS.



As foolish as this sounds, I believe that even advanced AIDS can be reversed. This doesn't mean that the HIV virus is going away. It will never completely go away. But people can live with the HIV virus IF and only IF the progession towards AIDS can be blocked. And it can.



First and foremost, hormone replacement doses of glucosteroids, such as methylprednisolone, should be given. This is critical in order to inhibit the synthesis of pro-inflammatory hormones and restore homeostatis in the body.



Second, a soluble form of zinc, zinc sulfate, should be given. Zinc is extremely anti-inflammatory and will downregulate the expression of the TNF and FAS membrane receptors. Zinc is also a powerful activator of the entire immune system via its ability to control the activity of a host of proteins that contain "zinc fingers".



Third, oxidative stress promotes the synthesis of TNF, etc. The glutathione mimic n-acetylcysteine should be used to reduce oxidative stress.



I will be discussing the role of zinc in controlling HIV infections in the next essay.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Thursday, July 17, 2008

The End of AIDS. Part One

This essay is reposted from our subscription blog in the public interest.

The following article, published in the 1994 edition of Discover Magazine, changed my life. I am an immunologist whose primary research interest is the effect of glucosteroids (hydrocortisone, dexamethasone, prednisone) on the immune system. After reading this article, I began to quietly cry. Finally, I knew what was driving the terminal phase of AIDS.



The article speaks for itself.



http://discovermagazine.com/1994/jun/adeadlymasquerad387



This woman was two days, max, away from dying of advanced AIDS. The physicians gave her a hormone replacement dose, probably of prednisone, and she walked out of the hospital three days later. In one month she had gained 25 pounds. Six months later she remained healthy and was back at work.



A hormone replacement dose is a small dose given to people who show signs of adrenal insufficiency. A pharmacological dose is used to treat serious inflammatory diseases. However, these high doses can only be taken for a short period of time.



A physician at the University of Pittsburgh has argued for years that a hormone replacement dose of glucosteroids can largely prevent shock and death. A pharmacological dose makes the situation worse, because the body senses the high concentration of hormone and blocks its ability to bind the glucosteroid receptor. This is a normal feedback response. This physician has been attacked for years by the medical whores who are paid consultants for the pharmaceutical industry. They want to sell expensive drugs to treat shock.



The following study shows that low glucosteroid doses inhibited inflammation and organ failure in shock, while high doses did nothing.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12553498&itool=pubmed_docsum



Shock basically refers to vascular collapse. When your blood pressure drops too low, you die. Inflammatory hormones such as TNF, tumor necrosis factor, are responsible for shock and death. Low doses of glucosteroids inhibit the synthesis of TNF, but high doses do not.



In the next essay, I will present current evidence that TNF, its receptors and other death hormones such as FAS are responsible for the progression from HIV infection to actual AIDS. This inflammatory response can be controlled or corrected by low dose glucosteroid therapy and/or zinc sulfate supplementation. I know it sounds too good to be true, but it is true.



Ms Kaye walked out of hospital because the low dose glucosteroid dose she was given terminated the inflammatory response that was killing her.



I gave a short talk over ten years ago to some AIDS doctors from UCSF in San Francisco. It was in the evening and everyone was tired and hungry. When I mentioned that low dose glucosteroid therapy could block the terminal phase of AIDS by inhibiting the inflammatory hormones driving the disease, no one responded. Except one woman physician who was listening intensively. She gave prednisone to an AIDS patients for some inflammatory problem and he disappeared. When she asked one of his friends about his wheareabouts, she was told that he was "off climbing mountains somewhere".



Touche.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Wednesday, July 16, 2008

PEITC, a Natural Compound Found Highly Concentrated in Watercress Effectively Kills Both Drug Resistant Chronic Lymphocytic and Myeloid Leukemia Cells

This essay is reposted from our subscription blog in the public interest.

All cancer and leukemia cells generate excessive amounts of ROS, or reactive oxygen species due to the nature of their metabolism. If the level of ROS is further elevated by chemotherapy or radiation, the cells self destruct. This is why cancer and leukemia cells are so dependent on glutathione synthesis for survival.



A new study has found that the depletion of glutathione, independent of oxygen stress, is THE key factor in the initiation of apoptosis (and autophagy and necrosis as well). Many enzymes require glutathione for their activity. As it turns out, certain key enzymes, yet unidentified, will initiate programmed cell death if they become inactive. This occurs even in the presence of non-thiol free radical scavengers.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17724027&itool=pubmed_docsum



PEITC increases oxidative stress in cancer and leukemia cells by forming a conjugate with glutathione. This conjugate is then exported from the cells, thereby reducing the level of free glutathione. PEITC also directly binds and inhibits the activity of glutathione peroxidase, an enzyme that scavenges certain species of ROS.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16959615&itool=pubmed_docsum



Chronic myeloid leukemia (CML) is a common form of leukemia that used to be universally fatal. This disease is now treatable with a drug called Gleevec. This drug is not a cure, but it does control the proliferation of the leukemic cells. Unfortunately, many people develop resistance to this very expensive drug. There are many forms of drug resistance, but in CML one form of resistance involves a mutation called T3151.



The following new study found that PEITC killed both Gleevec sensitive and insensitive CML cells with equal efficiency. As it does so at low PEITC concentrations (5 microM). The method by which PEITC kills these cells is by the induction of oxidative stress. The BCR-ABL enzyme that drives the proliferation of CML cells is destroyed by the oxidative stress. However, the depletion of glutathione by PEITC is the most important factor in cell death.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18385754&itool=pubmed_docsum



Chronic lymphocytic leukemia is the most common form of leukemia. This disease usually develops slowly, but it is largely considered incurable. One chemo drug, fludarabine, is commonly used in the treatment of CLL, but resistance rapidly limits its effectiveness. As in the CML studies, low concentrations of PEITC (5 microM) induce oxidative stress and kill CLL cells rapidly. PEITC has no affect on normal lymphocytes. The depletion of glutathione is the key factor in this form of programmed death.



http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18574029&itool=pubmed_docsum



We have three ways to reduce glutathione in cancer and leukemia cells. Glutamine, sodium selenite and now PEITC are important if not critical parts of our cytotoxic protocol. PEITC must be obtained by eating watercress.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Sunday, July 13, 2008

A Stressful Life Promotes the Development of Cancer

This essay is reposted from our subscription blog in the public interest.

My mother listens to talk radio at night. A few nights ago one station hosted a program on the increasing incidence of cancer in the US. It is increasing in epidemic proportions.



What causes cancer?, my mother asked. Stress, I replied. She thought I was joking. 



From the day you were born, cells in your body have regularly mutated. These mutated cells either self destructed by apoptosis, autophagy or necrosis or were killed by a very sophisticated immune system. Mutated cells, per se, are not cancer. In order for cancer to exist, these cells have to grow into tumors. If these cells are able to grow, something very fundamental is going wrong in your body.



The issue isn't whether these immortal cells are incapable of self destructing. The issue is why the immune system is not able to rapidly destroy them as soon as they develop.



Our crappy diets are one factor. Omega 6 oils such as soy, corn, and safflower are precursors of the fatty acid arachidonic acid. This fatty acid is converted into prostaglandins, such as PGE2, which increase the level of cyclic AMP in cancer and immune cells. This intracellular mediator is extremely immunosuppressive in addition to promoting angiogenesis and cancer cell metastasis in general.



However, I don't believe that diet alone can account for the increasing incidence of cancer. We have had crappy diets for a long time and the cancer rates did not suddenly explode. I believe psychological stress is the reason for the current increased cancer rates.



Think about it. Stress releases adrenaline from the adrenal glands and nor-adrenaline from nerves. These hormones increase the level of cyclic AMP in cancer and immune cells. This results in a DIRECT stimulation of cancer cell growth and metastasis and the inhibition of the immune response against the cancer cells. One study, published in Nature Medicine, showed that inducing behavioral stress in mice with tumors caused the cancers to spread like a prairie fire. I have been told by numerous women that their cancers did not spread until they experienced some form of psychological stress.



The world economy is in decline, people are losing their homes, jobs and their medical benefits, and we live in fear of additional wars. People are stressed out of their minds. Under these conditions, mutated cells, which always exist in our bodies, can and will develop into true cancers.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Friday, July 11, 2008

New Uses for Old Drugs

This essay is reposted from our subscription blog in the public interest.

I was digging through my old Nature magazines and I found a commentary entitled New Uses for Old Drugs. The authors stated that, on average, it takes 15 years and $800 million dollars to bring a new drug to market. The NIH, National Institutes of Health, budget in 2003 was $27 billion dollars. Yet despite this research expenditure, only 20-30 new drugs are approved by the FDA each year. And most, if not all, of these drugs are outside the financial reach of the poor or under/non insured. The authors recommended screening present drugs for new uses. I totally agree.



This is how the system works. If you invent a new compound, you can get a patent on the molecule itself and its use in the treatment of various diseases. If someone comes up with a different use for this drug, such as in the treatment of a different disease, they can file a new applications patent. They might not have a patent on the molecule itself, but they can prevent its use for the treatment of a new disease. Basically, it's a Mexican standoff between the owner of the patent for the molecule itself and the patent holder for its use in unique applications.



HOWEVER, if ONE scientific study has been previously published on the use of this molecule for pareticular unique purposes, that voids the application patent for that purpose because the information is now in the public domain. If a patent is not possible, no company in their right mind is going to pursue a particular line of research. Pharmaceutical companies aren't in business for love. They have to answer to their stockholders. In the interim, sick people suffer.



There are many, many generic drugs on the market that can be used to treat a wide diversity of "non-approved" diseases. And you don't even have to conduct a clinical trial. Physicians do NOT work for the FDA or other drug approval agencies. These agencies do not regulate the practice of medicine. The practice of medicine is licensed and controlled by state medical boards. Physicians can and do prescribe "off label" medicines all the time. BUT they have to have some scientific justification for doing so. Grouppe Kurosawa provides that scientific justification.



As an undergraduate at Reed College, I wrote a senior thesis on psychological factors which predispose people to develop cancer. I have been interested in this topic ever since. The relationship between health, disease and psychological factors is largely ignored by the medical community. When the book Type A Behavior and Your Heart was published 30 years ago, cardiologists ignored it. For some reason, they could not fathom the relationship between psychological stress and heart disease. And heart disease is just the tip if the iceburg. My brother-in-law has type 2 diabetes and a very stressful job in Silicon Valley. When he spends a relaxing weekend at Lake Tahoe, his blood sugar routinely drops WITHOUT the use of insulin. Stress does indeed play a role in the development and perpetuation of many diseases. Unfortunately, they do not teach this in medical school. As a result, physicians tend to ignore the human emotional response to the disease process and how it can completely subvert any and all treatments that they may prescribe.



In this essay, I want to talk about two "super" generic prescription drugs, an OTC drug, and a natural hormone that when combined can be used to treat an almost limitless number of diseases. No patents are involved, thank you very much. These drugs, plus additional compounds, will be incorporated into our new immunotherapy treatment protocol.



Part One. Cyclic AMP



Cyclic AMP is an intracellular signaling molecule that plays many roles in cell metabolism. For our purposes, it directly and indirectly inhibits the entire immune response to pathogens and cancer cells. It also promotes angiogenesis (blood vessel growth) and the growth and metastasis of cancer cells.



In general, cyclic AMP can be activated by two different classes of molecules. First, the prostaglandin PGE2 activates receptors that increase the level of cyclic AMP in cells. The role of PGE2 in the suppression of the immune response and promotion of cancer cell growth and development is VERY well known. Second, adrenaline (epinephrine) and nor-adrenaline (nor-epinephrine) activate beta 1 and 2 membrane receptors which increase the level of cyclic AMP in all cells of the body. Although beta receptors are fundamentally involved in promoting hypertension, they are less well known to also promote immunosuppression while directly enhancing the growth of cancer cells.



Both diet (PGE2 synthesis promoted by omega 6 oils such as corn, safflower, and soy oils) and psychological stress (adrenaline) promote immunosuppression and the direct activation of cancer cell growth and metabolism.



Part Two. MDA-7/IL-24



This hormone, synthesized in virtually all immune cells, is now considered to be the "magic bullet" for the treatment of cancer. It powerfully promotes apoptosis and autophagy via oxidative stress in cancer cells without affecting normal cells. Clinical trials are underway. The biological effects of MDA-7 are antagonized by the immunosuppressive hormone IL-10.



Part Three. Type I Interferon (alpha and beta)



These immune hormones were originally identified as inhibitors of viral synthesis and propagation. Over time it became apparent that these interferons also activated the entire immune system, including the development of dendritic cells. These hormones are also powerful inducers of apoptosis in cancer cells. The synthesis of these hormones is classically controlled by the activation of Toll receptors by viral products. It is now known that MDA-7 activates apoptosis in cancer cells via the activation of type I interferon synthesis.



Part Four. Histamine



There are four histamine membrane receptors. Only receptors 1 and 2 are relevent to the immune response. Tumors live in a "histamine bath" due to the migration of histamine secreting cells into the tumor environment. Although H1 receptors activate the immune response, H2 receptors do the exact opposite. They inhibit the secretion of IL-12, a critical hormone involved in cell medited immunity, while promoting the synthesis of IL-10, a powerful immunosuppressive hormone. Histamine H2 receptors activate cyclic AMP pathways.



THE FOUR AMIGOS



The two prescription generic drugs are sulindac and pindolol. I have posted many essays on the medical wonders of sulindac. I recently wrote about pindolol and its ability to at least partially over come the immunosuppression associated with psychological stress.



http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/07/the-new-immunot.html



Although pindolol was developed as an anti-hypertensive drug, its ability to block the secretion of nor-epinephrine into the blood and beta 1/2 receptor activity means that it could be used to both treat cancer and leukemia directly and as an activator of immune responsiveness. If our goal is to activate the immune response against cancer/leukemia, we MUST take psychological stress into consideration.



In addition to blocking PGE2 synthesis, sulindac promotes autophagy. It also significantly increases the effectiveness of MDA-7 by inhibiting its degradation in cells.



Histamine is both immunostimulatory and inhibitory depending on the number of H1 and H2 receptors on cells. H2 receptors are found on many, if not all, immune cells. When the H2 receptor is activated, the cell mediated immune response is turned off. The OTC drug cimetidine (Tagamet) blocks H2 receptor activity.



Melatonin is the final member of the FAB FOUR. This hormone activates primarily cell mediated immunity. Its importance in the control of cancer has been confired by a recent World Health Organization report suggesting that working the night shift is a carcinogen. When you are exposed to light at night, melatonin is not secreted from the brain. I am presently working on a new essay on melatonin and immune responsiveness. In addition to directly activating immune cells, melatonin also blocks the immunosuppressive properties of PGE2.



These inexpensive drugs can be used to treat a host of different diseases. All physicians need is a scientific reason to use them. We are trying to provide the international medical community with those reasons so they can make informed decisions. 



This information will be elaborated upon in future blog essays.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com

Sunday, June 29, 2008

An Exciting New Treatment for Brain Cancer

Selenium is a metal that is necessary for the functioning of many enzymes. In high concentrations, it depletes glutathione thereby inducing autophagy and apoptosis. I have written about these topics before.



http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2007/07/a-new-treatme-2.html



http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/03/sodium-selenite.html



In the first essay referenced, I recommended that liquid sodium selenite be introduced into the nose to treat brain cancer. SS does not harm normal neurons, but it does promote the death of gliomas by the depletion of glutathione.



The following is the story of a member whose breast cancer metastasized throughout her entire body, including the brain. There is no trace of cancer in her brain any longer.



Hi Steve,



Here is the story about the brain mets from my wife Ria.



My wife is suffering from breast cancer since 10 years. It has metastasized to the sternum, lungs, liver, neck, middle spine and lower spine.



In the past years she had all the treatments you can think of. In 2004 FAC chemo removed the mets in the lungs and made the tumour in the liver a lot smaller. The rest of this liver met we had removed by laser (LITT) in Frankfurt. They do not know the treatment in Holland.



The first time there was a met in the neck it was discovered too late by the doctors (actually they denied it). That is why my wife has two paralyzed hands and all of her fingers. So since three years she cannot do anything by herself. Just nothing at all, so I do it for her. She got radiation 5 times. After 8 months the tumor in the neck was back. Second time radiation (5 times).



One year later she had mets in the lower spine on different places. This meant that the cells were spreading through the liquor along the spine and the head. Radiation followed on lower spine.



Last October my wife had mets on the middle part of the spine. This time she got Taxol chemo. After three weeks of taxol (weekly) she got problems in the right side of her face and her right eye. MRI scan showed a tumour on the right side of the truncus cerebri (do not know the English translation) and different small mets all over the meninges in the head.



In November 2007 So then she got whole brain radiation. Five times (during one week). We had just started to take DHA – 15 capsules per day. (http://www.derooderoos.com/catalog/product_info.php?products_id=1980&osCsid=a7146936dd05b89878f63a5426bc458a



She continued taking these DHA capsules during radiation and after following you advise.



Just before the start of and radiation she had a ruffling sound an high sound in her right ear. The nerve from the truncus cerebri to the right eye and right side of the face goes through the right ear.



She had NO Dexamethasone. The sounds in the ear disappeared shortly after radiation was finished.



Two weeks after radiation we thought of clearing up possible rest mets by using Sodium Selenite drops (from LEF) in the nose. Clearing up not only in the head, but also in the rest of the liquor through which it has spread. On drop per day which she inhaled as advised in your protocol.  After two or three days the sounds in the ear were back. I thought it must have been the same ROS reaction as caused by the radiation.) So I thought a good sign. We stopped after the 5th day. The sounds disappeared again.



About one month after radiation we stopped the DHA capsules.



Next after every month we tried some maintenance by doing the Sod. Selenite drops in the nose for 5 days and stop taking the Sod. Sel. Capsules during these 5 days. I do not know if the drops and the capsules can be combined as you state in your protocol: NOT more then one drop per day.



In May 2008 (6 months after the radiation) an MRI scan was made from the head. There were NO signs of mets.



Apart from the present condition my wife is in at this moment I thought I should tell you about this experience. Still there are no signs that point at growing mets in the head.



Hope this information is useful for you.



Hope you understand my Dutch English well.



SUMMARY



Ria had 5 brain radiations during one week only.



No Dexamethasone (which inhibits apoptosis in cancer cells) was used to control brain inflammation.



They used DHA fish oil before radiation, during radiation and thereafter. One month after radiation DHA use was stopped.



Two weeks after radiation they inhaled one drop of LEF (lef.org) liquid sodium selenite in the nose for 5 days.



Every month thereafter they used sodium selenite in the nose for 4 or 5 days.



After 5.5 months the MRI scan showed no signs of cancer.



The radiation caused a ringing in Ria's right ear. When the the radiation stopped, the ringing stopped.



When sodium selenite was administered, the ringing (rubble) began again. They attribute this to the oxidative damage induced by both radiation and selenite in the cancer cells.



When selenite is now administered in the nose, there is NO ringing. They believe this confirms that the cancer is now cleared from the brain.



CONCLUSION



It is possible that radiation alone killed Ria's brain cancer, but I doubt it. I believe radiation, the absence of Dex and the use of sodium selenite accomplished this incredible cure.



Well done. Great feedback.



Stay tuned...



Grouppe Kurosawa, Medicine in the Public Interest



http://www.grouppekurosawa.com