Methyl Jasmonate. A Stage Four Lung Cancer Treatment Diary

In June 2008 my wife, Yevette, was diagnosed with stage 4 lung cancer. The cancer had spread to her adrenal gland, liver and brain by the time it was discovered. She immediately started radiation treatments and was preparing to start chemotherapy. In July after her last radiation treatment she developed pneumonia and spent 7 days in ICU on a by-pap machine in the regional hospital. The Doctors said if her O2 levels continued to drop she would have to go on a ventilator and would not be able to come off it. They advised us to prepare for the worst because they didn’t think she could pull through. She pulled through and surprised us all and was sent home with an O2 concentrator. She was too weak to start the chemo and In August she started swelling to the point that fluid was oozing from her skin, her primary physician started her on Lasix for the swelling, her potassium levels dropped and she had to be readmitted to ICU to get her potassium back up.

While in ICU it was discovered she had fluid around her lung. She had 1100 ml of fluid drained from her lung. Again the doctors told us to prepare for the worst, again she pulled through. 10 days later (September) I took her to the local hospital to have more fluid drained from her lung, this time 1600 ml was removed. Later that night her heart went into arterial fibrillation. She was transported to the regional hospital and again she was put into ICU. This time the Dr's told us there was nothing more they could do and sent her back to the local hospital to be closer to her friends and family. After several days in the local hospital she was sent home under Hospice care. By this time she was so weak she could not stand without assistance and could only move a couple of steps to get to the bedside toilet.

September 16  4 specialists, 1 ER admitting doctor and 1 general practitioner felt there was nothing else that could be done and that in a matter of days or hours she would die.

What they didn’t realize is that neither she nor I were willing to give up that easily.

September 18  I gave her the first treatment of Methyl Jasmonate using a Vick's Personal Steam Inhaler with 2 ml of methyl jasmonate (2 grams). She was not able to do the complete treatment because she was too weak to keep her head over the inhaler. Prior to the treatments she had very labored breathing, especially when she was sleeping and also had sleep apnea with 4 to 5 second pauses between breaths. This had been going on for over 2 years.

September 19  I started noticing an improvement in her breathing, she still had the apnea but she was no longer struggling to breath.

September 21  I noticed the swelling was reducing.

September 22  I stopped giving her Lasix, the swelling was still reducing.

September 24  I gave her the second treatment of MJ. She was still not able to complete the entire treatment. The swelling was still reducing and almost completely gone.

September 25  Her breathing is the best it has been in over 2 years and NO sleep apnea! The swelling is gone and she is getting stronger.

September 29  I gave her the third treatment of MJ. She was able to do most of the treatment. She is still getting stronger.

October 2 We went to see my wife’s primary doctor, He was very surprised to see that she had walked into his office (the two previous visits she was in a wheel chair). She had to use a walker but she made it under her own power. After listening to her breathing he said her lungs sounded much better. Her O2 saturation was checked while on 3 ml of oxygen and registered 100, the oxygen was removed and she was rechecked approximately 20 minutes later, her O2 saturation was 94. Her doctor told her that she no longer needed to be on oxygen all the time and she could use it when she felt short of breath. He wanted to know more about what we were doing. I told him we were using Methyl Jasmonate, he asked about the dosage and cost, when I told him he said “that’s cheaper than anything we can do”. He then said it looks like its helping and to keep him informed on her progress. She made the comment that she didn’t realize how sick she was the last time she was in ICU. Her doctor said “yes, they sent you back here to die” (that was an eye opener for her). She still needs help standing but can walk. There is no more swelling, her breathing is good, her lung sounds are good (not normal yet but getting there), her strength is slowly returning and she is much more alert. We have no doubt that the MJ treatments are benefiting her.

Her doctor said that normally as a general practitioner he would not order further tests on someone with her diagnosis but he was curious as to her remarkable improvement and scheduled her an appointment for October 23 for blood work and X-rays.

October 6 I gave her the fourth treatment of MJ. She was able to do almost all of the treatment again. About half way through the treatment she said her vision got a little blurry. About 45 minutes after the treatment she said her vision was back to normal.  She is still slowly getting stronger, and can now occasionally get up off the bed by herself. She is only wearing the O2 about half the time now and it is down to 2 lpm. She went all night without the O2.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Methyl Jasmonate and Lung Cancer

This essay is reposted from our subscription blog in the public interest.

I was contacted by a guy whose wife has stage four lung cancer. This is terminal and the oncologists won't treat her any more. He wanted methyl jasmonate for her treatment. I told him that MJ was her only hope since it could be inhaled directed into the lungs with a simple steam inhaler. He didn't have a PayPal account so his friend sent me the money. His friend, a woman named Georgie, is a real character. She told me that he knows that his wife is going to die, but he has to do something.
 
Well...the MJ worked and in a very short period of time.
 
This woman was confined to a wheel chair. She couldn't walk. Hell, she could barely breathe. She had such poor lung capacity that in the beginning she couldn't finish the weekly MJ/steam treatments.
 
A few days ago she visited her primary physician. With the help of a walker, she walked into his office under her own power. No wheel chair. He couldn't believe it. Her energy level is returning, she is more alert, and her lung functioning is almost back to normal. There is no question that MJ is inducing necrosis in her massive lung tumors. Otherwise, there is NO way that she could rebound this quickly. Programed cell death is a very slow process, but necrosis is immediate.
 
And they want to go on the record with their MJ treatments. They want the world to know that maybe, just maybe, lung cancer can be defeated with a simple compound like inhaled methyl jasmonate.  
 
And that's pretty cool. 

After she regains her strength and lung capacity back, maybe they can get a PET or CAT scan to positively document the reduction in tumor load. That would be incredible.

In the last few weeks, I have discussed the importance of targeting cancer stem cells in the treatment of cancer and leukemias. These cells are resistant to programmed cell death induced by chemo drugs and radiation. BUT, and this is a critical point, NO cell is resistant to a reduction in ATP levels resulting in necrosis. Methyl jasmonate is the most powerful inhibitor of ATP synthesis (necrosis) yet identified.

We are getting closer and closer every day to developing simple effective treatments for the treatment of cancers and leukemias.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

 

The Ultimate Cancer and Leukemia Treatment Protocol. CyclicAMP/PKA

This essay is republished from our subscription blog in the public interest.

In the previous essay, I discussed NF-kappaB and how it promotes the survival of cancer stem cells. In this essay I will discuss the growth factors for cancer and normal stem cells.

The WNT pathway stimulates the growth of both normal and cancer stem cells. The WNT complex exists on the outer membrane of cells. When stimulated, it activates a protein called beta-catenin that migrates into the nucleus to activate various genes. Over expression of the WNT/beta-catenin pathway is very common in cancers of all types. The following is an excellent review article on WNT signaling and cancer stem cell growth. It can be read online.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17979879&itool=pubmed_docsum

WNT signaling mediates resistance to radiation and chemotherapy in breast cancer stem and progenitor cells.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17979879&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18539959&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18519688&itool=pubmed_docsum

The presence of these resistant stem cells in the bulk cancer propulation is one of the reasons that the five year survival rate for chemotherapy alone in 22 different cancers is only 2%.

The enzyme GSK-3 forms a complex with beta-catenin and promotes its degradation in the proteasome. This is a feedback mechanism that prevents the excessive accumulation of beta-catenin in cells. Activators of cyclic AMP formation, via the further activation of protein kinase A, inactivate GSK-3 thereby allowing beta-catenin to remain active.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17990294&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16199882&itool=pubmed_docsum

Many hormones and compounds can increase the level of cyclic AMP/PKA in cells. The prostaglandin PGE2 and stress hormones epinephrine/norepinephrine are the major activators of cyclic AMP signaling.

We have many cyclic AMP signaling hormone inhibitors at our disposal. These will be discussed in the next essay.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

The Ultimate Cancer and Leukemia Treatment Protocol. NF-kappaB

This essay is reposted from our subscription blog in the public interest.

One of the most important anti-cancer/leukemia targets is the genetic factor NF-kappaB. In the last few years, it has become apparent that NF-kappaB is a critical factor for the continued survival of cancer stem cells. These stem cells are the ONLY cells that can promote the continued proliferation of cancer and leukemia cells.

As previously discussed, cancer and leukemia cells will die on their own if cancer stem cells are eliminated from the bulk of malignant cells. The average cancer/leukemia cell can propagate on its own for unknown generations, but eventually it will die. These cells, contrary to previous dogma, are NOT immortal. Cancer stem cells, on the other hand, are immortal. As long as they exist, the respective cancer or leukemia will not be eliminated from the body.

Three years ago a study was conducted showing that parthenolide, the active ingredient in feverfew, killed acute myeloid leukemia and chronic myeloid leukemia blast cell progenitor and stem cells. The target was NF-kappaB.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15687234&itool=pubmed_docsum

Unfortunately, parthenolide is insoluble in water and therefore poorly bioavailable. A synthetic form of parthenolide was developed that has 70% oral bioavailability. This compound induces the rapid death of primary stem cells from myeloid and lymphoid cell populations and is toxic to the bulk tumor load. Again, the target is NF-kappaB.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17804695&itool=pubmed_docsum

The following study, published in May of this year, did an extensive analysis of the cancer stem cells found in prostate cancers. They found that these cancer specific stem cells were pro-inflammatory. The four main pathways activated were JAK/STAT signaling, cell adhension and extracellular matrix interactions, focal adhesion signaling and WNT signaling. I will be discussing WNT signaling in the next essay. If parthenolide blocks the activation of NF-kappaB in these stem cells, the cells die of apoptosis. Normal stem cells are not affected.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18492237&itool=pubmed_docsum

Other studies have found that cancer stem cells do not contain an excessive amount of NF-kappaB. However, in cancer stem cells the NF-kappaB is chronically activated.

The following new study is very exciting in its implications. First, it shows that NF-kappaB inhibitors such as parthenolide preferentially inhibit breast cancer stem cells. Second, it compares and contrasts parthenolide with the chemo drug paclitaxel (Taxol) with respect to their efficacy against cancer stem cells and normal cancer cells.

At a low dose of 1 microM, parthenolide inhibits the growth of cancer stem cells by 40%, and normal cancer cells by 3%. When the dose is increased to 5 microM, parthenolide inhibited stem cell growth by 95% and normal cancer cell growth by 66%.

Paclitaxel, on the other hand, at a dose of 2.5 nanoM inhibited normal cancer cell growth by 50% and stem cell growth by 40%.

The authors found that a combination of parthenolide and paclitaxel acted synergistically to reduce tumor mass in cancer bearing mice.

We have two ways to reduce NF-kappaB in cancer cells. Glutamine is the first and parthenolide is the second. Parthenolide, due to its poor bioavailability, must be administered topically in a 70% DMSO gel. I have 99% pure parthenolide if anyone wants it. It cost $100 for 10 grams payable via PayPal. The PayPal payment address is smartin@grouppekurosawa.net. The 10 grams is mixed in four ounces of the DMSO gel, a standard commercial size. Parthenolide is effective in low concentrations so a little could go a long way.

In the next essay, I will discuss the WNT pathway that stimulates the growth of cancer stem cells. Cyclic AMP inhibitors, of which there are many, inhibit this pathway.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

 

The Ultimate Cancer and Leukemia Treatment Protocol. Overview

This essay is republished from our subscription blog in the public interest.

In 1995, a paper was published showing that AML, acute myeloid leukemia, was sustained by a unique population of self renewing stem cells. These stem cells have unique membrane markers and are highly resistant to radiation and chemotherapy drugs. If these stem cells are killed, AML as a disease ceases to exist.

In the last ten years, an increasing body of evidence has shown that cancer specific stem cells exist for almost all cancers, including breast, prostate, colon, pancreatic, liver, brain, osteosarcoma, and all leukemias.

When a "normal" cancer or leukemia cell divides, it produces two essentially identical cells. Since these cells have traditionally been considered "immortal", at least in contrast to normal cells, cancer cells can continue to grow without restraint.

Nothing could be further from the truth. So-called normal cancer cells are NOT immortal. In the absence of tissue specific stem cells, these cancer cells don't live very long. When a cancer stem cell divides, it produces two non-identical cells. One cell is a normal cancer cell while the other is another stem cell.

Years ago I read a study which fascinated me. This kind of study has been repeated many times with many different kind of cells.

Human breast cancer cells were treated with antibodies which targeted and killed the stem cells. The remaining breast cancer cells were injected into mice. No cancers developed. The injected cancer cells simply died on their own. As few as 100 cancer stem cells can cause cancers in mice, while thousands of stem cell depleted cancer cells cannot.

Clearly, cancer stem cells are the ultimate therapeutic target for the treatment of both cancer and leukemia. If we can narrow down our ultimate target, we have a real chance of completely eliminating cancer and leukemia from the body.

We can kill cancer stem cells by inhibiting the NF-kappaB and cyclic AMP/protein kinase A signaling pathways. It's that simple. The data will be presented in the following essays.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

A Natural Medicine Treatment for Primary Liver Cancer

Primary liver cancer (originates in the liver) and liver metastasis from other organs are considered fatal diseases. Maybe not...

The following email was recently sent to me by Larry, a Grouppe Kurosawa member.

Dr. Martin and fellow Kurosawa blog members:

I have an update to all. This is the post I  made on the GK discussion group on July 19th of this year:

The following is the protocol that I am currently on. I will post as to my progress and welcome anyone's feed back. I am battling to stay alive. I have been diagnosed with Primary liver cancer. I have a number of lesions in my liver, nowhere else. I am currently seeing an oncologist and taking a medication called Nexavar for Primary Liver Cancer (HCC) and have been on it for about a month. I will have MRI in Aug. to see about progress..
I was on the liver transplant list back in April but was bumped off because my cancer spread and I no longer met the criteria for the transplant.
So here I am.
Please, if anyone has any feedback, give it to me. I am currently other than severely fatigued because of the Nexavar, in very good health (ha ha)...no seriously, I am. My liver function is perfectly normal. I have great hope that something will break my way, but am also a realist. My attitude is excellent, God has given great strength and let me keep my sense of humor.
I really believe that what Dr. Martin is doing makes a lot of sense, much more that what I was doing before. At least there's science behind everything he is recommending here...

Glutamine 50g a day
Sodium Selenite 1 mg a day
Lithium Orotate  56.4mg a day
Policosanol 20mg a day
Vitamin B1 1g a day
Vitamin  D3 10,000 IU a day
Vitamin A 50,000 IU a day
Melatonin 10mg ea. night
Zinc Zulfate 50mg a day
Curcumin dissolved in Flax seed oil  12 g a day
Flax Hull lingans , SDG 30/60 mg/g 10g a day
Full Spectrum Amino Acid capsules (Prolab) 6 capsules a day

Ok. that was then. Now for the update. Please realize that I had primary liver cancer (HCC) since Jan. of '08 and the cancer was allowed to spread from Jan. until mid-June when I started on Dr. Martin's protocol and a pharmaceutical called Nexavar (a multi kinase inhibitor).

So, when I was checked at the end of Aug. the MRI showed that lesions had grown in size and cancer had progressed but had not metatastized. I also had blood work which showed normal liver function. The oncologist told me that it could be the medication was not working and that she was suprised liver function was still normal but to expect the worst. They were going to check me with CT-scan in 6 weeks and do labs in 2 weeks.

I called Dr. Martin and told him of the setback. He proposed that I up the ante. The following is the protocol I have been doing since end of August:

Glutamine 70g a day ( I weigh 190 lbs.)
Sodium Selenite 1 mg a day
Lithium Orotate  56.4mg a day
Policosanol 20mg a day
Benfotiamine (more bioavailable form of B1 or thiamine)  1 g + 500 mg a day
Vitamin  D3 10,000 IU a day
Vitamin A 1000,000 IU a day
Zinc Zulfate 50mg a day
Flax Hull lingans , SDG 30/60 mg/g 10g a day
 And added:
Cimetidine 1g a day
Sulindac  600 mg a day
DCA 1 g a day dissolved in the l-Glutamine and water  (started this Sept. 7)
3 or 4 cups of double strength Black tea (two tea bags)

In a few days I am going to add:

Mebendazole (the worm pill) 100 mg 2x a day for 5 days and then see how I feel. And discuss with Dr. Martin.


Got the labwork back yesterday (Sept.9) and oncologist said to me..."I am really quite suprised, your liver function is perfectly normal! And your liver is normal size, soft, as normal as mine. Maybe something is working because clinically you are stable. This is a good deal. I am going to look into clinical trials for you at M.D. Anderson and Baylor because as long as you are clinically stable you have for options for treatment."

So. I went from you don't have long to live at end of Aug. to "maybe something is working'? this past week. I, of course, don't know what is going on but can tell you that I have very good energy during the day, I sleep well at night , eat and breathe normally. This is a big deal. I am prepared to die but at the same time I will take any bit of light that comes my way and dance with it.

Will up date Dr. Martin in Oct. when I have my Cat-Scan . Hope this helps someone. I know one thing, Dr. Martin's protocol has caused me no adverse effects, there is a lot of good science behind everything he is recommending. To me, it is a no brainer.

One more thing: In August after my MRI my oncologist who knew I was juicing every morning said "STOP JUICING". Dr. Martin has over and over said 'NO ANTIOXIDANTS!"
I am convinced. They feed your cancer.

Onward through the fog...as we used to say in my college days. Nothing has changed really.  I will keep all you good people in my thoughts and prayers.

Larry B.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

A Successful Natural Medicine Treatment for Stage Four Breast Cancer

GS is a member of the GK Blog who lives in New Delhi India. His mother's stage four breast cancer was considered terminal. We worked together to change his mother's current treatment protocol to one that I believed would be more effective. GS asked lots of questions. We spoke on the phone many times. He wasn't going to do anything just because I said so. At present, his mother has no cancer in her body. It is gone except for some lymph nodes lodged between her liver and pancreas. We don't know if these lymph nodes are lymphomas, or inflammed lymphoid organs. The following is his story.

PAST HISTORY
My mother was diagnosed with an advanced form of Breast cancer in feb 2005. She was immediately
operated upon her left breast and the connecting lymphnodes were removed. This was
followed by Chemo therapy of just Dosetaxol, the CT scan detectable signs of cancer
were gone in 3 months, the chemo continued, severe side effects befell upon her.

Just 8 months later her BP one day went up to 200 by 140 and with a severe pain
in her head she developed double vision due to her right eye. Then suddenly this double
vision started to turn into a right sided paralysis, parkinson’s like shaking and severe lack
of motor control in just 4 days with inability to speak or swallow.
Upon mri investigations they found her dural meningis to be swollen along with her
cerebellum at the base of her brain. The Wbc and protein in her cerebro spinal fluid were
elevated.

This could mean she had a cancer speading to her brain or / and autoimmune disease
called paraneoplastic syndrome or meningitis. None of these could be established.... as
we couldnt take her CSF again and again, they take the CSF 4 times to rule out cancer mets or
Paraneoplastic syndrome. Upon Further CT Scans they found a pea sized tumour at the lymph site where surgery was done and a lymphatic spread was found on her liver as well, the stomach and one
adrenal gland appeared bulky, there was also a metastatic lymph node under the liver.
She was put through radiation of the cerebellum before chemo with dexamethasone.

While the radiations were on we switched our oncologist upon being told that radiation should not be
done before chemo, the doc also said the breast surgery shouldnt have been done till after the chemo
and the lymph nodes not removed. The new oncologist administered gemcite and carboplatin over 18 doses and everything cleared up over CT scan prognosis.
We needed to get a Chemoport installed in her chest before the chemo which is still flushed
every 30 days with 5-10 ml of Heparin.The liver had a scar with a fatty deposit from the cancer assault. The doctor said the disease had been well controlled.
The double vision was now almost gone but persisted due to shaking of the eye.
She still has a lot of physical weakness, lack of motor control and inability to walk
and speak. Her physical symptoms are more like a severe parkinson’s case.
My mom still had severe lack of appetite, mild indigestion, acidity, belching, feels
very cold, weak.

WHAT WE DID TO PREVENT CHEMO AGAIN AND AGAIN.

By this time we realized that we would be there torturing my mom with chemos every year once a
year then every couple of months till the chemo took her life.
This is what we are did immediately after to fight the disease:

On 1st of Jan 2007 she started taking 15 grams of MSM which has made here veins which
hadnt revived in over 2 years start appearing in just 1 month. She took atleast 8 grams of
msm a day religiously and was unable to pass off a decent stool without it, so she enjoyed it, sadly
these were the few pleasure she had left besides her rosary which she had chanted all her life and still
chants for several hours till today.

She took a 100 mg Vitamin B, 1 gram of C, 1 gram of coral calcium, 400 mg of CoQ10
daily We’ve only stopped Coq10 a week before the ultrasound of the liver mentioned
below.VShe took 1 softgel of flax oil which also contains fish oil to go with the q10 this is going
on without the q10 right now. Extra 1mg of folic and B12 each also taken without fail to combat pernicious anaemia.1/3rd to 1 teaspoon of Curcumin with piperine this is being off and on, she says it helped
her feel warmer, q10 made her feel cold.
She took Some kind of a multivitamin complex for seniors iron-free daily we used many brands.
The latest one was Vitacost version 2 one a day formula it contains 200 mcg niacin bound chromium.
After that for about 4 months she been took a herbal mixture ( almost 1 cup ) containing one
branch Aloevera juice, Wheatgrass juice, 12 leaves neem, 1 gram
Withania Somnifera root, 6 inches of Tinospora cordifolia stem, and 7 leaves of Dark holy basil. This formula was given to us by a herbalist he asked us to add periwinkle flowers as well but we didn’t because we feared we might need vinchristine or vinbalstine chemo in future. It turns out a couple of these herbs
She did a month of oral laetrile protocol and for 5 months she got gastric side effects couldn’t take it
anymore.

During this time she started using the Dr. clark Zapper twice a day, and 4.5 grams of IP6
blended with 1 gram inositol (cellforte )
She also took 1 mg melatonin and 1.5 mg alprazolam to sleep. 4 mg
EMSET – (Zofran, Ondansetron) for nausea daily
She needed 2.5 mg of amlovas (amlodipine) for hypertension – her
Blood pressure was then 5-12 point below the upper and lower limit – we stopped amlovas.
Her blood pressure became 120 - 122 / 80 without the pill.

Liver Ultrasound:
Due to her very poor appetite we got a liver ultrasound done.
The findings / comments were as follows:
Liver - measures 13.2 cm craniocaudally in mid clavicular line (normal is < / = 15.5) –
the radiologist verbally commented its slightly small during the scan. No evidence of any
focal parenchymal lesions noted. IHBR is normal, Portal and hepatic veins are mormal is
course and caliber. Portal vein measure 8mm (normal is < /= 13mm) she didn’t comment
anything here. Mild coarse Echotexture.

Gallblader- well distentedwith clear lumen and normal wall thickness, no calculus seen
CBD – normal in caliber
Spleen – normal in size (7.3 cm) and echotexture. No forcal or diffuse lesion seen
Both kidneys = are normal is size, she position and echotexture. No evidence of any
calculus or hydronephrosis.
There is a small precaval lymphnode posterior to pancreas measuring 1.2 x 1.7 cm
in size - This could definitely be cancerous. We were scared so we found Dr. Martin.
I explained the whole protocol we had done for my mother so far to Dr. Martin and he was kind
enough to push forward his Cytotoxic oxidative stress protocol ahead of schedule for my mom.
I was Extremely grateful to him

This is what we did with the protocol:
The protocol we did lasted for 40 days total so far.
this included (and none of the old protocols):
1 MG SODIUM SELENITE divided
40 - 50 GMS L-GLUTAMINE
10-15 GMS ISOLEUCINE
25000 -50000 IU BETACAROTENE (STARTED ON THE 10TH DAY)
2 POLICOSANOLS IN DIVIDED DOES A DAY
2-3 TEASPOONS OF SWANSONS SDG FLAX LIGNANS (STARTED ON THE 15TH DAY
FOR 8 DAYS)
2000 IU VITAMIN D A DAY FOR 20 DAYS
A CONCOCTION OF 7 LEAVES HOLY BASIL 7 LEAVES NEEM IN SOME WHEATGRASS
JUICE and Wormwood tincture (artimisinin)
ZAPPING WITH THE DON CROFT ZAPPER ORIGINALLY DR. HULDA CLARKS DESIGN
(ELECTRICITY TO KILL PATHOGENS) This is the first time we felt a zapper actually works
10 MG OF MELATONIN STARTED ON THE 30TH DAY
1 HEAPED TEASPOON OF SODIUM SALICYLATE FIRST THING IN THE MORNING IN A
GLASS OF WATER (25 DAYS)
2-2.5 SULINDACS Pills A DAY (40 DAYS)
2 tabs LITHIUM OROTATE HANS NEIPER BRAND A DAY

She took a drop of Lugols iodine everyday in water – I bought book saying this can be a singular
treatment for breast and prostate cancer. Breast Cancer and Iodine" by Dr. David Derry
Read about Dr. Derry on Natural NEWS.com
The vitamin d overload caused hypercalcemia then i started with some K2 did it for week but we
were scared it might clot her chemo port
she comfortably takes 2000 iu of Vitamin D a day now.

This is how Dr. Martins protocol helped.
1. Her appetite came back immediately in a week
2. Her mood started to improve she felt more happy than sad
3. She started to gain weight again
4. Her hair started to grow again
5. The Blood pressure stated to rise again – im waiting for the Pindolol to arrive from the US
6. Her self confidence started to rise again and we started to go out on a wheel chair for
outings (please keep in mind she is clinically 70% + disabled)
7. The speech cleared up tremendously for the first time it was severely slurred.
8. My mom used to get up twice every night to go to urinate to the bathroom.... one of us
carry her on a chair to take her there and put her on the pot. She sleeps soundly till 6 in
the morning and goes just once to urinate now at 6 am.

Immediately after the protocol we went in for a PET scan and decided to see to the original good
oncologist.
The most important Para in the PET scan report read.
'' There is evidence of an FDG avid (SUV Max:11.3) heterogeneously enhancing Necrotic lymph
nodal mass at the porta measuring approx. 2.2 x 1.0 x 2.8 cm (AP x TR x CC)
It is encasing the portal Vein and abutting the head of the pancreas. Fat planes between the head
of the pancreas and liver appear indistinct.
Mildly FDG avid lymph node with heterogeneous peripheral enhancement is also noted in the
aortocaval region measuring 1.2 x 1.4 x 2.3 cm ''

The next day when my dad went to my moms clinical oncologist at XXXX Hospital.
He waited 5 hours before his turn.... We were really glad he met the doctor - You ll read why?
The man is a noble person and probably the busiest oncologist in Asia maybe the world.
He is head oncology of 4 hospitals in India, starts with a smiling and patient face at 7:30 in
the morning sees 250 - 300 patients a day in different parts of Asia and India.
Finishes his day at 8pm and then goes to individual Wards to see his patients.
He some how manages to remember everyones case history by face.
He does this all smilingly on a Wheelchair - and you can tell his old mans smile is true simple
and genuine.

The Dr. was shocked to see my dad? He remembered it had been a long time.
There were 3 other doctors in the room (his assistants - also oncologist)
My dad handed him the PET scan reports and the History.
He said '' Mr. XXXX - you are handing me CLEAN scan reports of a Stage 4 patient
after 20 months'' how has this happened?
''ALL her organs are clean - you are obviously doing something good to your wife and its working
-- You dont know how happy you've made me today ''
----at this 2 other doctors got up from their chairs to see the reports themselves.
The Doctor then said '' Mr. XXXX Please just keep doing what your doing - its working ''
He asked my dad for the biopsy analysis Which read ---- ER PR weakly positive and HER2 1+
---- so the doctor said as far as I go these figures are treated as negative, and then wrote
LETROZOLE tab SUGGESTED (humbly)

Were not off the Hook yet – im scared about the pancreas. Im going to use D- limonene with
sulindac Watercress and Vitalica Gel caps (40 mg SGS) instead of the broccosprouts. Will also use Beta
glucans in the immunotherapy phase --- the Video on YouTube  by Dr. Boncini – that cancer is like a
fungus is really amazing – Beta glucans is a potent macrophage activator and its derived from yeast cell
wall so it might train the immune system to attack cancer--- it cant hurt so this will be besides Dr.
Martins protocol.

Tried the Mebendazole my moms appetite went for a Strike Out the first day. Might go back to the
Half maximal cytotoxic dose with all the other things to get rid of the Nodules. Might even do the
minimal DCA with minimal caffeine and B1 – there is no way we will know if she ever had brain
mets. We would rather take out the cancer slowly if her life is not in danger . By the way the liver
looked good on the pet scan and normal size too.

Thank You Dr. Martin – You had promised youd come true as her Angel of Health and you did.
We still have a lot of work to do. Im going to Try and give you the Study by Dr. Henry Lai about
electricity and cancer. It does no harm, but might kill cancer stem cells passing through the vein.
She has not caught a cold in 20 months.

One more thing I always check the words angiogenesis when I look up a HERB or nutrient on
cancer. If it shuts down angiogenesis its good enough. By the way fat soluble B1 increases angiogenesis to repair nerves I think I read it somewhere. I may be wrong but Im just trying to say be careful...
look up all your stuff based on the cytotoxic and cytoprotective pathways Dr. Martin mentions
just be sure you dont goof up. Dont over do oxidative stress Dr. Martin uses only safe levels of
ROS in his protocols and talk to him based on your patients weight and condition use your own
head.

This is to all of you stage 4 breast cancer patients out there all I want to say is '' There is still hope were hopeful and so we came till here '' If you feel you were helped in anyway by this letter please pray for my mom –she is all I got and my only wealth. Your prayer can be just one line from the heart.

Love
G.S.
Ps. When I was young my mom would give me money to chant my rosaries and pray. I developed faith
in God in my early years thanks to her. She is like a little 5 ft angel to me full of prayers love and
gentleness. Please pray for her - she is all I got.

SUMMARY

GS is a very intelligent man who knows how to listen. When we discussed his previous protocol, he did not take offense when I objected to almost everything he was doing. In my experience, some people become addicted to their current protocol and don't want to change. Invariably, this resistance to change costs them their lives. My biggest problem is convincing people that anti-oxidants promote cancer cell growth. A few days ago a client told me that his oncologist told him to stop juicing. The juiced ingredients could interfere with his treatment. Of course, FRESHLY juiced fruits and vegetables contain lots of anti-oxidants. This didn't occur to me before.

I would like to thank GS for the feedback and kind remarks. If you are reading this essay on the Public Blog, please send this essay out to anyone who has breast cancer. Stage Four breast cancer does not have to be a terminal disease.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

The Anti-Ulcer Drug Cimetidine (Tagamet) is a Powerful Anti-Cancer Drug

This essay is republished from our subscription blog in the public interest.

Cimetidine, the generic version of the popular anti-ulcer drug Tagamet, is a potentially powerful anti-cancer drug, especially if combined with other compounds.

If you conduct a PubMed search on cimetidine and cancer you will find over 1000 references.

The epidermal growth factor receptor (EGFR) is over expressed on carcinoma cells. These epithelial cells comprise over 80% of all cancers. Blocking the activity of these receptors is the subject of many research projects.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18337605&itool=pubmed_docsum

This study shows that common, inexpensive, non-toxic cimetidine blocks the activation of EGFR. When EGF, epidermal growth factor, binds EGFR it initiates an autophosphorylation reaction which activates the receptor and its tyrosine kinase activity. Cimetidine blocks this response, thereby blocking EGFRs ability to promote cancer cell growth and the inhibition of apoptosis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17295779&itool=pubmed_docsum

The authors found that cimetidine decreased the level of cyclic AMP in the cancer cells. The lack of cyclic AMP impaired the autophosphorylation of the EGFR and inhibited its activity. This is an observation of monumental significance. Other histamine H2 receptor inhibitors, such as ranitidine and famotidine, do not decrease the level of cyclic AMP in cells.

I have written extensively about the prostaglandin PGE2 and its ability to suppress the immune response in general and its ability to promote angiogenesis and the growth of cancer cells. PGE2 promotes the synthesis of cyclic AMP. I have also written about the role stress hormones, such as norepinephrine and epinephrine, play in inhibiting the immune response and promoting cancer cell growth and development. These hormones also activate cyclic AMP synthesis.

Cimetidine could decrease cyclic AMP levels in cells by blocking membrane adenylate cyclase, the enzyme that actually makes cyclic AMP, or by increasing the activity of cyclic AMP phosphodiesterase, the enzyme that degrades cyclic AMP. To date, no one knows how cimetidine influences cyclic AMP levels in cells.

Cimetidine, probably via decreased cyclic AMP levels, decreases the development of regulatory T cells. These cells, referred to as TREG, suppress immune functioning. These cells are activated by the immune hormones IL-10 and TGF-beta, hormones that cimetidine downregulates. In addition, cimetidine activates the synthesis of IL-12, the major enhancer of cell mediated immunity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18502198&itool=pubmed_docsum

There are two major forms of TREG immune inhibitor cells. These cells inhibit a vigorous immune response against cancer, leukemia, bacterial and viral infections, such as HIV.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18613849&itool=pubmed_docsum

The IL-10/TGFbeta hormones responsible for the activation of this subset of TREG cells is inhibited by cimetidine due to its ability to reduce cyclic AMP levels in cells.

The second subset, FOXP3 TREG cells, is also activated by cyclic AMP. This implies that cimetidine can inhibit this population of TREG cells as well.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16785520&itool=pubmed_docsum

The implications of this line of research are enormous. Cimetidine, by lowering cyclic AMP levels in cells, can reactivate the immune response against cancer, HIV and other diseases while inhibiting angiogenesis and the growth of cancer cells.

The daily dose is 800 mgs a day, 200 mgs four times a day. And you don't need a prescription.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Worm Pills, an Effective Treatment for Malignant Melanoma and Other Cancers

This essay is reposted from our subscription blog in the public interest.

Mebendazole is a generic, inexpensive prescription medicine used to treat worm infections. This drug is called a spindle poison because it interrupts the formation of microtubules, cellular filaments that separate newly made DNA. Chemo drugs such as Taxol and alkylating agents are also spindle poisons, but they have toxicities that mebendazole does not have.

http://en.wikipedia.org/wiki/Mebendazole

http://www.mayoclinic.com/health/drug-information/DR600879

In the last few years, a number of studies have found that mebendazole is a powerful inducer of apoptosis in a wide variety of cancer cells, both in culture dishes and mouse models.

In the following study, half maximal cytotoxic doses of mebendazole in the range 0.1 to 0.8 microM (VERY low) killed a wide diversity of cancer cells, including lung, breast, ovary, colon and osteosarcomas. These studies were also conducted in mice. Mebendazole also inhibited angiogenesis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12231542&itool=pubmed_docsum

Unlike microtubule disruptive drugs such as Taxol and alkylating agents, mebendazole does not harm normal cells.

The following study was published this month. It shows that mebendazole kills two different strains of chemotherapy resistant melanoma cells. One strain contained a mutant p53 protein while the other harbored a normal p53 tumor suppresor protein. Mebandazole kills the cells equally. The half maximal cytotoxic dose was 0.32 microM.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18667591&itool=pubmed_docsum

Cimetidine, the generic version of the anti-ulcer drug Tagamet, promotes the toxicity of mebendazole by inhibiting its degradation in the liver.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3663452&itool=pubmed_docsum

The average blood concentration of mebendazole after a single clinical dose is 1.67 microM. This value vastly exceeds the concentration of mebendazole needed to kill a host of different cancer cells.

Mebendazole is usually sold as a chewable tablet. When chewed and allowed to remain in the mouth for a short period, the mebendazole can enter the blood through the mucosal membranes of the mouth. Of course, it can also enter the blood via the GI tract. This drug is extremely non-toxic even in doses of 4.5 grams a day.

Microtubule inhibitors are THE target of interest for chemo drugs. In this case, a simple anti-worm drug inhibits microtubule functioning at low non-toxic concentrations. In a culture dish and in mice, mebendazole induces apoptosis in a diversity of cancer cells at extremely low concentrations.

Unfortunately, this drug will NEVER enter clinical trials as a treatment for cancer.  There is no money to be made.

Fortunately, physicians can prescribe this drug for the treatment of cancer without a clinical trial. This blog and the referenced articles contain all the scientific justification that they will need.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

CDC Under Estimates New HIV Infections in US

CDC understated number of new HIV infections in US
By MIKE STOBBE, AP Medical Writer 28 minutes ago

The number of Americans infected by the AIDS virus each year is much higher than the government has been estimating, U.S. health officials reported Sunday, acknowledging that their numbers have understated the level of the epidemic.

The country had roughly 56,300 new HIV infections in 2006 — a dramatic increase from the 40,000 annual estimate used for the last dozen years. The new figure is due to a better blood test and new statistical methods, and not a worsening of the epidemic, officials said.

But it likely will refocus U.S. attention from the effect of AIDS overseas to what the disease is doing to this country, said public health researchers and officials.

"This is the biggest news for public health and HIV/AIDS that we've had in a while," said Julie Scofield, executive director of the National Alliance of State and Territorial AIDS Directors.

The revised estimate by the Centers for Disease Control and Prevention and the methodology behind it were to be presented Sunday, the opening day of the international AIDS conference in Mexico City.

Since AIDS first surfaced in 1981, health officials have struggled to estimate how many people are infected each year. It can take a decade or more for an infection to cause symptoms and illness.

One expert likened the new estimate to adding a good speedometer to a car. Scientists had a good general idea of where the epidemic was going; this provides a better understanding of how fast it's moving right now.

"This puts a key part of the dashboard in place," said the expert, David Holtgrave of Johns Hopkins University.

Based on the new calculations, officials believe annual HIV infections have been hovering around 55,000 for several years.

"This is the most reliable estimate we've had since the beginning of the epidemic," said Dr. Julie Gerberding, the CDC's director. She said other countries may adopt the agency's methodology.

According to current estimates, around 1.1 million Americans are living with the AIDS virus. Officials plan to update that number with the new calculations, but don't think it will change dramatically, a CDC spokeswoman said.

The new infection estimate is based on a blood test that for the first time can tell how recently an HIV infection occurred.

Past tests could only detect the presence of HIV, so determining which year an infection took place was guesswork — guesswork upon which the old 40,000 estimate was based.

The new estimate relies on blood tests from 22 states where health officials have been using a new HIV testing method that can distinguish infections that occurred within the last five months from those that were older.

The improved science will allow more real-time monitoring of HIV infections. Now, CDC officials say, the estimate will likely be updated every year.

Yearly estimates allow better recognition of trends in the U.S. epidemic. For example, the new report found that infections are falling among heterosexuals and injection drug users.

Some experts celebrated that finding, saying it's a tribute to prevention efforts, including nearly 200 syringe exchange programs now operating in 36 states despite a federal ban on funding for such projects.

But they also lamented the CDC's finding that infections continue to increase in gay and bisexual men, who accounted for more than half of HIV infections in 2006. Also, more than a third of those with HIV are younger than 30.

Some advocates say that suggests a need for more prevention efforts, particularly targeting younger gay and bisexual men.

For years, AIDS was considered a terrifying death sentence, and since 1981, more than half a million Americans have died. But medicines that became available in the 1990s turned it into a manageable chronic condition for many Americans, and attention shifted to Africa and other parts of the world.

Last week, President Bush signed a $48 billion global AIDS bill to continue a program that he called "the largest commitment by any nation to combat a single disease in human history."

But some advocates complain that CDC's annual spending on HIV prevention in the United States has been held to roughly $700 million since 2001, while costs have risen. (That's about 3 percent of what the federal government spends on AIDS; much of the rest is on medicines, health care and research.)

The new estimate is "evidence of a failure by government and society to do what it takes to control the epidemic," said Julie Davids, executive director of the Community HIV/AIDS Mobilization Project.

Whether more funding comes or not, the revised estimate clearly is a "wake-up call to scale things up," said Dr. Kevin Fenton, who oversees CDC's prevention efforts for HIV/AIDS.

Some said more attention needs to focus on prevention among blacks, who account for nearly half of annual HIV infections, according to the new CDC report.

A recent report by the Black AIDS Institute concluded that if black Americans were their own nation, they would rank 16th in the world in the number of people living with HIV.

"We have been inadequately funding this epidemic all along. We need to step it up," said former U.S. Surgeon General Dr. David Satcher, who is now an administrator at Atlanta's Morehouse School of Medicine.

The new estimate has been anticipated for a long time. The CDC began working on the new methods nearly seven years ago.

Late last year, advocates said they had heard the figure was about 55,000 and pressed the CDC to release it. Agency officials declined, saying they were submitting their research for medical journal review.

"These are extremely complicated statistical methods," and CDC officials wanted the work to be thoroughly reviewed by outside experts, Gerberding said. CDC's findings are being published in the Journal of the American Medical Association.

Until 1992, the number of diagnosed AIDS cases was used to predict how many people were newly infected each year. That method produced an estimate of 40,000 to 80,000. More recently, the CDC focused on infections among men who have sex with men, who account for about half of new HIV diagnoses.

___

You Could Have Heard a Pin Drop

When in England , at a fairly large conference, Colin Powell
was asked by the Archbishop of Canterbury if our plans for Iraq were
just an example of empire building' by George Bush.

He answered by saying, 'Over the years, the United States has
sent many of its fine young men and women into great peril to fight
for freedom beyond our borders.
The only amount of land we have ever asked for in return is enough to
bury those that did not return.'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
There was a conference in France where a number of international

engineers were taking part, including French and American. During a
break, one of the French engineers came back into the room saying
'Have you heard the latest dumb stunt Bush has done? He has sent an
aircraft carrier to Indonesia to help the tsunami victims. What does
he intended to do, bomb them?'

A Boeing engineer stood up and replied quietly: 'Our carriers
have three hospitals on board that can treat several hundred people;
they are nuclear powered and can supply emergency electrical power to
shore facilities; they have three cafeterias with the capacity to feed
3,000 people three meals a day, they can produce several thousand
gallons of fresh water from sea water each day, and they carry half a
dozen helicopters for use in transporting victims and injured to and
from their flight deck. We have eleven such ships; how many does
France have?'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

A U.S. Navy Admiral was attending a naval conference that
included Admirals from the U.S. , English, Canadian, Australian and
French Navies. At a cocktail reception, he found himself standing with
a large group of Officers that included personnel from most of those
countries.

Everyone was chatting away in English as they sipped their
drinks but a French admiral suddenly complained that, whereas
Europeans learn many languages, Americans learn only English.' He then
asked, 'Why is it that we always have to speak English in these
conferences rather than speaking French?'

Without hesitating, the American Admiral replied 'Maybe it's
because the Brits, Canadians, Aussies and Americans arranged it so you
wouldn't have to speak German.'

You could have heard a pin drop.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

AND THIS STORY FITS RIGHT IN WITH THE ABOVE...

Robert Whiting, an elderly gentleman of 83, arrived in Paris by
plane. At French Customs, he took a few minutes to locate his
passport in his carry on.

'You have been to France before, monsieur?' the customs
officer asked sarcastically.

Mr. Whiting admitted that he had been to France previously.
Then you should know enough to have your passport ready.'
The American said,''The last time I was here, I didn't have
to show it.

'Impossible. Americans always have to show your passports on
arrival in France !'

The American senior gave the Frenchman a long hard look. Then
he quietly explained, ''Well, when I came ashore at Omaha Beach on
D-Day in 1944 to help liberate this country, I couldn't find a single
Frenchmen to show a passport to.'

You could have heard a pin drop.

Well said.

Grouppe Kurosawa, Medicine in the Public Interest
http://www.grouppekurosawa.com


________________________________

The End of AIDS. Part Five

This essay is republished from our subscription blog in the public interest.

Adam, our first and only HIV success story, took at my recommendation 1.2 grams of ibuprofen a day for three months before he began our "formal" HIV treatment protocol. In retrospect, I believe the use of ibuprofen, a Cox-1 and Cox-2 inhibitor, contributed substantially to the rebound in his immune response against the HIV virus.

MAIDS, a form of mouse AIDS caused by a similar retrovirus, is completely reversed by the use of Cox-2 inhibitor drugs. Cox-2 enzymes produce PGE2, a powerful prostaglandin that increases the level of cyclic AMP in cells. Cyclic AMP, acting via the protein kinase A enzyme, is extremely immunosuppressive.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15344910&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11387259&itool=pubmed_docsum

When the HIV surface protein gp120 binds its CXCR4 co-receptor, it induces the synthesis of cyclic AMP and activates the protein A kinase pathway in infected and non-infected cells. This results in T cell anergy in normal cells. Anergy means the immune cells fail to respond to antigens. GP120 also activates the synthesis of Cox-2 via NF-kappaB.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12972513&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17627037&itool=pubmed_docsum

Protein kinase A is both immunosuppressive and an inducer of immunological tolerance. Tolerance means the immune response is literally taught to ignore certain antigen. This is an appropriate response AFTER an immune response has outlived its usefulness. However, if tolerance is induced early in an immune response, say against HIV viral proteins, the immune cells cannot recognize the viral proteins. Now you have a really big problem on your hands.

The Cox-2 inhibitor that we will use in this protocol is acetaminophen, Tylenol. This drug specifically blocks Cox-2 activity while leaving Cox-1 enzyme activity largely intact. In the presence of supplements such as n-acetylcysteine, acetaminophen does not cause liver damage. NAC is part of our HIV treatment protocol.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17884974&itool=pubmed_docsum

Psychological stress also plays a role in promoting the development of AIDS.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16314608&itool=pubmed_docsum

A current study at UCLA found that mindfullness meditation increases the CD4 T cell count and slows the progression of HIV. The study has not be published yet.

Almost all immune cells have beta1 and beta2 receptors on their membranes. These receptors bind adrenaline (epinephrine) and noradrenaline (norepinephrine) which increase the level of cyclic AMP in cells. Beta blockers are well known anti-hypertensive drugs. The medical and scientific communities have not come to grips with the role stress plays in the disease progression associated with HIV infections and cancer/leukemia. If the immune response is compromised by psychological stress, any and all efforts to increase immune responsiveness are rather pointless.

The best beta blocker is a drug called pindolol. Walmart sell a 3 months supply for $10. This drug blocks both beta 1 and 2 receptor activity. Further, it inhibits the release of noradrenaline from nerve endings. Noradrenaline is very immunosuppressive.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12458033&itool=pubmed_docsum

Pindolol is prescribed off label by physicians as a treatment for anxiety. The use of this drug will help control the immune suppression associated with psychological stress.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Glutamine and HIV

This essay is reposted from our subscription blog in the public interest.

Thus far, I have written over 1500 medical blog essays. As a result, I sometimes forget what I have already written. In the protocol essays, I forgot to mention that glutamine activates the synthesis of heat shock proteins.

Glutamine stimulates the synthesis and promotes the stability of the heat shock protein hsp-70.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18596307&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17599724&itool=pubmed_docsum

Glutamine, like low level glucosteroids, can protect against sepsis and shock. However, the glutamine response is completely dependent on the presence of HSP-70. Mice genetically deficient in HSP-70 are not protected by infusions of glutamine. The following review article, which can be read online, is an excellent review of the relationship between glutamine and HSP-70.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17234954&itool=pubmed_docsum

The term heat shock is actually a misnomer. These proteins protect the body against a wide variety of stressors, including excessive heat. HSP-70 protects the body against inflammation by inhibiting the activation of the genetic factor NF-kappaB. This well studied genetic factor activates the synthesis of a host of different pro-inflammatory immune hormones, including TNF. The inhibition of this factor is a major goal in the clinical control of cancer.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18282612&itool=pubmed_docsum

NF-kappaB is necessary for the activation of the HIV gene in infected cells.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16488488&itool=pubmed_docsum

In addition to its intracellular role, HSP-70 is also released from the cell into the tissue spaces. There it forms a complex with the membrane chemokine receptor CCR5, thereby blocking the infection of new CD4 T cells by certain strains of the HIV virus.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17251296&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16909434&itool=pubmed_docsum

In macrophages, HSP-70 forms a complex with the viral protein VPR, thereby preventing this viral protein from promoting the import of the virus into non-dividing macrophages.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15166037&itool=pubmed_docsum

VPR is also known to induce G2 arrest and death in infected CD4 T cells. HSP-70 prevents this response.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15142379&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15331702&itool=pubmed_docsum

I believe that AIDS, the final phase of HIV infection, can be strongly reversed by a combination of low dose hormone replacement glucosteroids and 50 grams, minimum, of the amino acid glutamine. For those who cannot get a prescription of these anti-inflammatory steroids, high glutamine doses may partially suffice. Glutamine can be purchased in bulk for $25USD/1 kilogram. The source is listed on our www.grouppekurosawa.com home page in the supplement file at the top of the page. We have no financial arrangement with this firm. They ship worldwide.

High doses of glutamine cannot be used in phase two of our treatment protocol. In this phase, we NEED NF-kappaB to be activated. NF-kappaB is necessary for the activation of both the innate and adaptive immune systems. Glutamine is obtained from the diet once the appetite returns.

Glutamine, by virtue of its ability to stimulate the synthesis and stability of HSP-70, is a powerful, inexpensive and non-toxic treatment for severe HIV infections.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

The End of AIDS. Summary

In this essay, I am going to attempt to put together a viable HIV treatment protocol. I have tried this in the past, but the protocols did not work to my satisfaction. Go here goes...

First and foremost, the final phase of the disease, AIDS, must be reversed. I realize that this sounds impossible but it really isn't. AIDS, in my opinion, is characterized by a steadily progressing glucosteroid insensitivity. Virtually every clinical symptom associated with AIDS is identifical to that associated with adrenocortical insufficiency. Methylprednisolone, in low hormone replacement doses, has been used to block proinflammatory induced shock and death. This hormone can also be used to block the extreme inflammatory response that drives HIV infections into AIDS. Further, it can be used to reverse AIDS into a more benign viral infection, while restoring total body homeostasis.

Glutamine, in 50 gram doses, 25 grams twice a day in juice, is used to complement the low dose glucosteroid treatment. Glutamine also inhibits PI-3K/AKT signaling, thereby causing the death of long term viral reservoirs in macrophages.

ONLY glutamine and methylprednisolone are used to reverse AIDS. NOTHING ELSE.

Once AIDS is reversed, we can breathe freely while we attempt to erradicate the virus from the body.

When the body has stabilized and appetite and strength have returned, we can drop the methylprednisolone and concentrate on reactiving the immune response against the virus.

Low hormone replacement doses of methylprednisolone are not immunosuppressive. That is a contradiction in terms.

I want to strongly emphasize that the CD4 T cell count is irrelevant for our purposes here. It is a poor indicator of clinical status. There are people who have CD4 T cell counts of 10 who are not sick. Naturally, their innate immune response is still functioning. The innate arm of cellular immunity has nothing to do with CD4 T cells.

Second phase.

Hopefully, the glucosteroids have substantially reduced reduced the synthesis of TNF and other pro-inflammatory hormones that drive HIV infections into AIDS.

In this phase, we will use 50 mgs of elemental zinc per day. Zinc sulfate capsules of 220 mgs or so contain about 45-50 mgs of actual zinc. I capsule per day. The bottle will tell you how much zinc is present in each capsule. Do not exceed 50 mgs of zinc a day.

As I have written, zinc activates the entire immune response. Zinc also specifically activates PI-3K/AKT signaling, which is absolutely required for T cell development.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17509519&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17371229&itool=pubmed_docsum

Glutamine and arginine are necessary for proper immune functioning. If your appetite has returned, a person can get all the necessary glutamine and arginine from the diet. Arginine is found in high concentrations in nuts. High dose glutamine supplements are not necessary in this phase.

Alpha lipoic acid and n-acetylcysteine, taken together, will help to rebuild the glutathione levels in the body. Glutathione is necessary proper immune functioning. It is usually depleted in HIV infections.ALA works in the presence of retroviral drugs, but NAC does not. Together, they may help to increase the CD4 T count in the presence of these drugs. But don't hold your breath. Retroviral drugs are immunosuppressive. They may drop the viral titer, but they rarely increase the CD4 T cell counts.

The ALA dose is 300 mgs three times a day. The NAC dose is 600 mgs twice a day. ALA will also regenerate vitamin C and vitamin E in the body. You can take these supplements also, but not in excessive doses.

Acetaminophen is used to inhibit HIV induced PGE2 synthesis. This prostaglandin, via its activation of cyclic AMP, is very immunosuppressive. The dose is 2 grams a day, 1 gram twice a day.

Pindolol, a generic prescription drug, is used to block psychological stress induced immunosuppression. The dose is determined by your physician.

Summary

The immune system is quite durable. If you can remove the toxic factors which inhibit its activity, such as excessive TNF, FAS, and TRAIL apoptosis responses, it will regenerate itself.

In the first phase, we are attempting to enhance glucosteroid responsiveness using low dose hormone replacement doses. This will act to inhibit the inflammatory response that is driving the disease. Glutamine restores homeostasis in the body, while killing long term macrophage viral reservoirs by blocking PI-3K/AKT activity.

In the second phase we are attempting to support an enhanced immune response against the virus. We are not attempting to "activate" the immune response against the virus. The HIV virus and virally infected cells are very immunogenetic. In the absence of interfering factors, the immune cells will rapidly clear the virus. Thousands if not millions of people have been exposed to the HIV virus yet they remain healthy. Many of these people are seronegative, which means that the virus didn't last long enough in the body to stimulate an antibody response.

Pass this series of essays along to your friends. I realize that many physicians are afraid to prescribe glucosteroids to HIV infected persons because of a fear of immunosuppression. Hormone replacement doses are not immunosuppressive.The hormone replacement dose is only temporary anyway, but it MUST be used. If you don't inhibit the activity of the death hormones TNF, FAS and TRAIL, the disease process will continue. If you have money or insurance, you can elect to remain on HIV drugs until they eventually fail. Of course, your immune system will never reestablish itself due to the immunosuppressive nature of these drugs. Unfortunately most of the world has no access to these drugs so protocols like this are ideal.

It's worth a try. Nothing else is working.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com/